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FLASH GENE
Symbol NRBP1 contributors: mct - updated : 03-09-2007
HGNC name nuclear receptor binding protein 1
HGNC id 7993
Location 2p23      Physical location : 27.651.472 - 27.665.122
Synonym name
  • multi domain putative nuclear protein
  • nuclear receptor binding protein
  • myeloid leukemia factor 1 adaptor molecule
  • Synonym symbol(s) MADM, BCON3, MUDPNP, NRBP
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     18 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked   status confirmed
    regionally located near the location of NCOA1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestiveesophagus   highly
    Endocrinepancreas   highly
     thyroid   moderately
    Reproductivefemale systemuterus  moderately
     male systemtestis  highly
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines in tumor cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal PEST sequence
  • a putative binding domain for SH2 domain containing proteins
  • a protein kinase domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nrbp1 (98.32 pc)
    homolog to chicken NRBP1 (88.72 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text Co-localizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
    basic FUNCTION
  • adaptor protein potentially linking signaling pathways involving nuclear receptors
  • may play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases
  • negatively regulating AP1 activity when associated with COPS5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MLF1
  • interacting with RAC3
  • COPS5 (NRBP1 inhibits COPS5-induced phosphorylation of c-Jun and AP-1 activation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS