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FLASH GENE
Symbol NRAS contributors: mct - updated : 06-05-2013
HGNC name neuroblastoma RAS viral (v-ras) oncogene homolog
HGNC id 7989
Corresponding disease
NS6 Noonan syndrome 6
Location 1p13.2      Physical location : 115.247.078 - 115.259.515
Synonym name
  • v-ras neuroblastoma RAS viral oncogene homolog
  • N-ras protein part 4
  • transforming protein N-Ras
  • Autoimmune Lymphoproliferative Syndrome, Type IV
  • Synonym symbol(s) NRAS1, N-ras, ALPS4, HRAS1
    DNA
    TYPE functioning gene
    STRUCTURE 12.44 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 4461 - 189 - Taparowsky (1983)
    - splicing 4300 - - - Taparowsky (1983)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node   highly
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GTP-GDP binding sites
  • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nras (99.5pc)
    homolog to rattus Nras (99.5pc)
    intraspecies homolog to neuroblastoma Ras viral (v-ras) oncogene
    Homologene
    FAMILY
  • GTPase superfamily
  • RAS gene family (C-Hras1 and C-Hras2)
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,Golgi
    text
  • attached to the membrane by a lipid anchor, at internal side of plasma membrane
  • associated with both the outer membrane and inner mitochondrial compartments
  • membrane protein that shuttles between the golgi apparatus and the plasma membrane, shutlling regulated through palmitoylation and depalmitoylation (Rocks 2005)
  • basic FUNCTION
  • possessing intrinsic GTPase activity
  • has an immune regulatory function and its absence or gain-of-function affects primarily hematopoietic cells
  • having a farnesylation independent function and within the inner mitochondrial compartment being an essential component of the retrograde signaling system between the mitochondria and nucleus
  • tumor type–specific mutation spectrum of Ras genesis dictated by their regulation of expression and that the altered Ras proteins that can be palmitoylated act as particularly potent oncoproteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • CHMP6 and VPS4A bound to NRAS but not KRAS
  • DDX43 may promote NRAS protein expression by unwinding and stabilizing NRAS mRNA, therefore enhancing its translation
  • cell & other
    REGULATION
    activated by a GTPase activating protein
    inhibited by a guanine nucleotide-exchange factor
    ASSOCIATED DISORDERS
    corresponding disease(s) NS6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in multiple myeloma, in primary plasma cell leukemia at an early stage, and in thyroid cancer with poor prognosis
    tumoral germinal mutation     gain of function
    in autoimmune lymphoproliferative syndrome
    tumoral somatic mutation      
    in high hyperdiploid childhood acute lymphoblastic leukemia
    tumoral somatic mutation      
    in hepatocellular carcinoma
    tumoral somatic mutation      
    in primary melanocytic tumours of the CNS, GNA11 and NRAS mutations represent a mechanism of MAPK pathway activation alternative to the common GNAQ mutations( :
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    effect of Nras loss on tumor development in Rb1 heterozygous mice, the loss of the protooncogene Nras in certain cellular contexts can promote malignant tumor progression (Takahashi 2006)