Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NRAP contributors: npt/ - updated : 10-07-2008
HGNC name nebulin-related anchoring protein
HGNC id 7988
Location 10q25.3      Physical location : 115.348.583 - 115.423.805
Synonym symbol(s) N-RAP
DNA
TYPE functioning gene
STRUCTURE 75.22 kb     42 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PDCD4 10q24 programmed cell death 4 (neoplastic transformation inhibitor) SHOC2 10q25 soc-2 suppressor of clear homolog (C. elegans) ADRA2A 10q25 adrenergic, alpha-2A-, receptor KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1 MGC35062 10q26.11-q26.12 Similar to RIKEN cDNA 1700011F14 gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
41 - 5417 193 1695 - Mohiddin (2003)
42 - 5522 197 1730 - Mohiddin (2003)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a LIM domain
  • HOMOLOGY
    interspecies ortholog to murine Nrap
    Homologene
    FAMILY
  • nebulin family of giant myofibrillar proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • helping anchor myofibril terminal actin filaments to the membrane
  • involved in actin filament organization and muscle contraction
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text muscle development, cell shape and cell size control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS