basic FUNCTION
| nuclear receptor involved in the organogenesis |
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required for the formation of commissural projections in the forebrain by regulating axonal growth (Armentano 2006) |
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orphan nuclear receptor promoting ventral cortical fate, cell cycle exit and neural differentiation, regulating the balance of early- and late-born neurons, and the balanced production of different types of layer V cortical projection neurons (Faedo 2008) |
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action regulation of the transcription of GNRH1 |
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transcription factor binded to the ovalbumin promoter and, in conjunction with another protein stimulating initiation of transcription |
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central role in the induction of the TNFAIP8 promoter by TNFalpha (Zhang 2009) |
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with NR2F2 play roles in amacrine cell differentiation (Inoue 2010) |
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controls the timing of birth and specification of corticospinal motor neurons (CSMN) in somatosensory cortex via repression of a CSMN differentiation program (Tomassy 2010) |
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exerts critical areal and temporal control over the precise differentiation of corticospinal motor neurons during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise (Tomassy 2010) |
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directly represses Rnd2 expression at the post-mitotic level along the rostrocaudal axis of the mouse neocortex |
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modulates late-born neuron migration and favours proper differentiation of late-born callosal projection neurons by finely regulating Rnd2 expression levels |
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suppresses synergistic activation of the MTTP promoter by HNF4A/HNF1A by binding to a direct repeat 1 (DR1) element |
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regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems |
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role in the adult brain as a key regulator in the control of sensory-dependent plasticity in olfactory dopaminergic neurons |
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has an important role in the development of the visual system and that haploinsuffiency can lead to optic atrophy with intellectual impairment |