Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NR2F1 contributors: npt/mct/shn - updated : 12-03-2014
HGNC name nuclear receptor subfamily 2, group F, member 1
HGNC id 7975
Corresponding disease
OAID optic atrophy with intellectual disability.
Location 5q15      Physical location : 92.919.042 - 92.929.778
Synonym name
  • COUP transcription factor 1
  • COUP transcription factor I
  • COUP-TF I
  • COUP-TF1
  • V-erbA-related protein 3
  • chicken ovalbumin upstream promoter-transcription factor I
  • transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3)
  • Synonym symbol(s) COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1
    DNA
    TYPE functioning gene
    STRUCTURE 10.75 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S2499 - D5S2100 - NR2F1 - D5S652 - D5S644 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3210 46 423 - 2010 20007910
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     adrenal glandmedulla   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulating domain
  • a central bipartite zinc finger
  • DNA binding domain
  • a C terminal ligand domain
  • HOMOLOGY
    interspecies ortholog to Nr2f1, Mus musculus
    ortholog to Nr2f1, Rattus norvegicus
    ortholog to NR2F1, Pan troglodytes
    Homologene
    FAMILY
  • steroid/thyroid hormone receptor superfamily
  • steroid receptor superfamily
  • CATEGORY regulatory , transcription factor , protooncogene , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • nuclear receptor involved in the organogenesis
  • required for the formation of commissural projections in the forebrain by regulating axonal growth (Armentano 2006)
  • orphan nuclear receptor promoting ventral cortical fate, cell cycle exit and neural differentiation, regulating the balance of early- and late-born neurons, and the balanced production of different types of layer V cortical projection neurons (Faedo 2008)
  • action regulation of the transcription of GNRH1
  • transcription factor binded to the ovalbumin promoter and, in conjunction with another protein stimulating initiation of transcription
  • central role in the induction of the TNFAIP8 promoter by TNFalpha (Zhang 2009)
  • with NR2F2 play roles in amacrine cell differentiation (Inoue 2010)
  • controls the timing of birth and specification of corticospinal motor neurons (CSMN) in somatosensory cortex via repression of a CSMN differentiation program (Tomassy 2010)
  • exerts critical areal and temporal control over the precise differentiation of corticospinal motor neurons during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise (Tomassy 2010)
  • directly represses Rnd2 expression at the post-mitotic level along the rostrocaudal axis of the mouse neocortex
  • modulates late-born neuron migration and favours proper differentiation of late-born callosal projection neurons by finely regulating Rnd2 expression levels
  • suppresses synergistic activation of the MTTP promoter by HNF4A/HNF1A by binding to a direct repeat 1 (DR1) element
  • regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems
  • role in the adult brain as a key regulator in the control of sensory-dependent plasticity in olfactory dopaminergic neurons
  • has an important role in the development of the visual system and that haploinsuffiency can lead to optic atrophy with intellectual impairment
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text neurotransmitter receptor
    PATHWAY
    metabolism
    signaling
    a component novel NR2FI complex with TNFAIP8 that functions as a repressor of transcription and may play a role in the TNFalpha signaling pathways (Zhang 2009)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinoid X receptor, RXR
  • S300-II/TFIIB
  • Sp1
  • estrogen receptor, ER
  • Alien
  • aryl hydrocarbon receptor, AHR
  • GRIP1 and SRC-1
  • human estrogen receptor alpha, hER alpha
  • Thyroid hormone receptor, TR
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • may be an important factor to modulate expression of genes that are repressed by T(3)
  • expression of RND2, a modulator of radial migration, is complementary to both these gradients and strongly increases in the absence of NR2F1 function
  • involved in the regulatory modulation of the expression of at least two genes, CYP26A1 and HOXA1
  • cell & other
    REGULATION
    activated by transcriptionally activated by all-trans retinoic acid (RA)
    ASSOCIATED DISORDERS
    corresponding disease(s) OAID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • COUP-TFI mutant mice late-born callosal projection neurons are delayed in reaching the cortical plate and have morphological defects during migration
  • axonal elongation and dendritic arborization are impaired in late-born callosal projection neurons of mouse COUP-TFI-deficient