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FLASH GENE
Symbol NR2C2 contributors: mct - updated : 20-03-2015
HGNC name nuclear receptor subfamily 2, group C, member 2
HGNC id 7972
Location 3p25.1      Physical location : 14.989.235 - 15.090.778
Synonym name
  • nuclear hormone receptor TR4
  • testicular orphan receptor-4
  • Synonym symbol(s) TR4, TAK1, TR2R1, hTAK1
    DNA
    TYPE functioning gene
    STRUCTURE 101.54 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure 21843524
    MAPPING cloned Y linked   status confirmed
    Physical map
    NUP210 3p25.2-p25.1 nucleoporin 210 HDAC11 3p25.1 histone deacetylase 11 FBLN2 3p25-p24 fibulin 2 WNT7A 3p25 wingless-type MMTV integration site family, member 7A FLJ35107 3p25.1 hypothetical protein FLJ35107 LOC391515 3 similar to putative pheromone receptor gV1R1 FLJ31709 MGC3222 3p25.1 hypothetical protein MGC3222 XPC 3p25.1 xeroderma pigmentosum, complementation group C LSM3 3p25.1 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) SLC6A6 3p25-p24 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 GRIP2 3p24-p23 glutamate receptor interacting protein 2 LOC131973 3p25.1 similar to rhomboid family 1; epidermal growth factor receptor, related sequence LOC51244 3p25.1 hypothetical protein LOC51244 DKFZP434N1817 3p25.1 hypothetical protein DKFZp434N1817 FGD5 3p25.1 FYVE, RhoGEF and PH domain containing 5 NR2C2 3p25 nuclear receptor subfamily 2, group C, member 2 MRPS25 3p25 mitochondrial ribosomal protein S25 ZFYVE20 3p25.1 zinc finger, FYVE domain containing 20 LOC344875 3p25.1 similar to RIKEN cDNA E330026B02 CAPN7 3p24 calpain 7 SH3BP5 1q43 SH3-domain binding protein 5 (BTK-associated) LOC389097 3 similar to Nonhistone chromosomal protein HMG-17 (High-mobility group nucleosome binding domain 2) MGC24132 3p25.1 hypothetical protein MGC24132 EAF1 3q25.1 ELL associated factor 1 COLQ 3p24.2 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase HPCL2 3p25.1 2-hydroxyphytanoyl-CoA lyase BTD 3p25 biotinidase KIAA0379 3p25.2-p24.2 biotinidase LOC131961 3p25.1 similar to inosine monophosphate dehydrogenase 1 isoform a; sWSS2608 GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) MGC15763 3p25-p24 hypothetical protein BC008322 RAFTLIN 3p25.1 raft-linking protein DAZL 3p24 deleted in azoospermia-like
    RNA
    TRANSCRIPTS type messenger
    text with two isoforms,short TR4ORA2,long TR4ORA1
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 8330 - 615 ubiquitous 1996 8661150
    TR4ORA1
    - - 2800 - - testis 1996 8661150
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
     brainhindbraincerebellum predominantly Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central bipartite (class II) zinc finger,
  • a N terminal modulator domain,
  • a DNA binding domain
  • a C terminal ligand domain with multiple ligand-binding domains
  • HOMOLOGY
    Homologene
    FAMILY nuclear receptor subfamily 2, goup C
    k1 steroid/thyroid hormone receptor superfamily
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • granule cell of the hippocampus and cerebellum
  • activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes
  • basic FUNCTION
  • playing a a role in the regulation of gene expression in specific cell types; in the testis, control gene expression during spermatogenesis, particularly during the meiotic phase
  • might function as an apoptosis modulator through induction of BCL2 gene expression
  • NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer
  • required for normal cerebellar development and that failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior
  • play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system
  • functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
  • plays a pivotal role in fundamental biological processes across different cell types
  • ligand-regulated nuclear receptor suggesting that retinoids might have a much wider regulatory role via activation of orphan receptors such as NR2C2
  • modulates DNA repair specifically through the transcription-coupled (TC) nucleotide excision repair (NER) pathway but not the global genomic NER pathway
  • modulates UV sensitivity by promoting the TC-NER DNA repair pathway through transcriptional regulation of ERCC6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • physiological role of NR2C1/NR2C2 heterodimers in germ cell development
  • oxidative stress-FOXO3-NR2C2 pathway is a fundamentally important mechanism regulating stress resistance and cell survival
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AR
  • MAPKBP1 interacted with not only NR2C2, but also with its upstream regulators, TNF-receptor associated factors 2 and 6 (TRAF2 and TRAF6)
  • NR2C2 transactivated SLC27A1 5prime promoter activity via direct binding to the NR2C2 responsive element located at the FATP1 5prime promoter region
  • directly regulates ERCC6 at the transcriptional level
  • existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with NR2C2
  • PELI2 is required for NR2C2-dependent NFKB activation
  • TAB2 and TAB3 are dispensable for NR2C2 activation in B cells, indicating that TAB2 and TAB3 activate MAPKs via a pathway independent of NR2C2
  • RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1
  • interactions of UBASH3A with nondegradative polyubiquitin chains, NR2C2 and IKBKG, suggesting that UBASH3A regulates the NFKB1 signaling pathway by an ubiquitin-dependent mechanism
  • cell & other
    REGULATION
    activated by retinol ,which indicates an expanded signaling network of vitamin A beyond the classic retinoic acid-RAR pathways
    repressed by JAZF1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS