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Symbol NR2C2 contributors: mct - updated : 20-03-2015
HGNC name nuclear receptor subfamily 2, group C, member 2
HGNC id 7972
Location 3p25.1      Physical location : 14.989.235 - 15.090.778
Synonym name
  • nuclear hormone receptor TR4
  • testicular orphan receptor-4
  • Synonym symbol(s) TR4, TAK1, TR2R1, hTAK1
    TYPE functioning gene
    STRUCTURE 101.54 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure 21843524
    MAPPING cloned Y linked   status confirmed
    Physical map
    NUP210 3p25.2-p25.1 nucleoporin 210 HDAC11 3p25.1 histone deacetylase 11 FBLN2 3p25-p24 fibulin 2 WNT7A 3p25 wingless-type MMTV integration site family, member 7A FLJ35107 3p25.1 hypothetical protein FLJ35107 LOC391515 3 similar to putative pheromone receptor gV1R1 FLJ31709 MGC3222 3p25.1 hypothetical protein MGC3222 XPC 3p25.1 xeroderma pigmentosum, complementation group C LSM3 3p25.1 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) SLC6A6 3p25-p24 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 GRIP2 3p24-p23 glutamate receptor interacting protein 2 LOC131973 3p25.1 similar to rhomboid family 1; epidermal growth factor receptor, related sequence LOC51244 3p25.1 hypothetical protein LOC51244 DKFZP434N1817 3p25.1 hypothetical protein DKFZp434N1817 FGD5 3p25.1 FYVE, RhoGEF and PH domain containing 5 NR2C2 3p25 nuclear receptor subfamily 2, group C, member 2 MRPS25 3p25 mitochondrial ribosomal protein S25 ZFYVE20 3p25.1 zinc finger, FYVE domain containing 20 LOC344875 3p25.1 similar to RIKEN cDNA E330026B02 CAPN7 3p24 calpain 7 SH3BP5 1q43 SH3-domain binding protein 5 (BTK-associated) LOC389097 3 similar to Nonhistone chromosomal protein HMG-17 (High-mobility group nucleosome binding domain 2) MGC24132 3p25.1 hypothetical protein MGC24132 EAF1 3q25.1 ELL associated factor 1 COLQ 3p24.2 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase HPCL2 3p25.1 2-hydroxyphytanoyl-CoA lyase BTD 3p25 biotinidase KIAA0379 3p25.2-p24.2 biotinidase LOC131961 3p25.1 similar to inosine monophosphate dehydrogenase 1 isoform a; sWSS2608 GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) MGC15763 3p25-p24 hypothetical protein BC008322 RAFTLIN 3p25.1 raft-linking protein DAZL 3p24 deleted in azoospermia-like
    TRANSCRIPTS type messenger
    text with two isoforms,short TR4ORA2,long TR4ORA1
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 8330 - 615 ubiquitous 1996 8661150
    - - 2800 - - testis 1996 8661150
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
     brainhindbraincerebellum predominantly Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    Respiratoryrespiratory tracttrachea  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • a central bipartite (class II) zinc finger,
  • a N terminal modulator domain,
  • a DNA binding domain
  • a C terminal ligand domain with multiple ligand-binding domains
    FAMILY nuclear receptor subfamily 2, goup C
    k1 steroid/thyroid hormone receptor superfamily
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
  • granule cell of the hippocampus and cerebellum
  • activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes
  • basic FUNCTION
  • playing a a role in the regulation of gene expression in specific cell types; in the testis, control gene expression during spermatogenesis, particularly during the meiotic phase
  • might function as an apoptosis modulator through induction of BCL2 gene expression
  • NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer
  • required for normal cerebellar development and that failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior
  • play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system
  • functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
  • plays a pivotal role in fundamental biological processes across different cell types
  • ligand-regulated nuclear receptor suggesting that retinoids might have a much wider regulatory role via activation of orphan receptors such as NR2C2
  • modulates DNA repair specifically through the transcription-coupled (TC) nucleotide excision repair (NER) pathway but not the global genomic NER pathway
  • modulates UV sensitivity by promoting the TC-NER DNA repair pathway through transcriptional regulation of ERCC6
    a component
  • physiological role of NR2C1/NR2C2 heterodimers in germ cell development
  • oxidative stress-FOXO3-NR2C2 pathway is a fundamentally important mechanism regulating stress resistance and cell survival
    small molecule
  • interacting with AR
  • MAPKBP1 interacted with not only NR2C2, but also with its upstream regulators, TNF-receptor associated factors 2 and 6 (TRAF2 and TRAF6)
  • NR2C2 transactivated SLC27A1 5prime promoter activity via direct binding to the NR2C2 responsive element located at the FATP1 5prime promoter region
  • directly regulates ERCC6 at the transcriptional level
  • existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with NR2C2
  • PELI2 is required for NR2C2-dependent NFKB activation
  • TAB2 and TAB3 are dispensable for NR2C2 activation in B cells, indicating that TAB2 and TAB3 activate MAPKs via a pathway independent of NR2C2
  • RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1
  • interactions of UBASH3A with nondegradative polyubiquitin chains, NR2C2 and IKBKG, suggesting that UBASH3A regulates the NFKB1 signaling pathway by an ubiquitin-dependent mechanism
  • cell & other
    activated by retinol ,which indicates an expanded signaling network of vitamin A beyond the classic retinoic acid-RAR pathways
    repressed by JAZF1