basic FUNCTION
| playing a a role in the regulation of gene expression in specific cell types; in the testis, control gene expression during spermatogenesis, particularly during the meiotic phase |
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might function as an apoptosis modulator through induction of BCL2 gene expression |
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NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer |
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required for normal cerebellar development and that failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior |
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play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system |
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functions as a fatty acid sensor to modulate CD36 expression and foam cell formation |
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plays a pivotal role in fundamental biological processes across different cell types |
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ligand-regulated nuclear receptor suggesting that retinoids might have a much wider regulatory role via activation of orphan receptors such as NR2C2 |
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modulates DNA repair specifically through the transcription-coupled (TC) nucleotide excision repair (NER) pathway but not the global genomic NER pathway |
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modulates UV sensitivity by promoting the TC-NER DNA repair pathway through transcriptional regulation of ERCC6 |
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