protein
| NR0B1 is a corepressor of NR1H3, functioning as a negative regulator of lipogenic enzyme gene expression in liver |
|
regulatory functions of AEBP1 on PPARG1 and NR1H3 transcriptional activity in the context of macrophage cholesterol homeostasis and inflammation |
|
binds to the proximal regions of the PLIN1 and LIPE promoters |
|
interaction of NR1H3 with CORO2A requires SUMOylation (possible involvement of deSUMOylating enzymes in negatively regulating NR1H3 repression functions) |
|
CIDEA binds to liver X receptors (NR1H2, NR1H3) and regulates their activity (could therefore be of importance for the regulation of metabolic processes in human adipose tissue) |
|
MID1IP1 is a mediator for stimulation of lipogenesis by NR1H2, NR1H3 activation in the liver |
|
suppressive action of PIAS1 on NR1H2, NR1H3-activated gene expression programs, particularly in lipogenesis |
|
macrophage IL5 is a target gene for NR1H3 activation, and the induction of macrophage IL5 expression can be related to NR1H3-inhibited atherosclerosis |
|
ASXL2 increased NR1H3 activity through direct interaction in the presence of the ligand, but ASXL1 suppressed ligand-induced NR1H3 transcriptional activity |
|
inhibits IFNG -induced biological responses, and IFNG is a new molecular target of NR1H3 |
|
PRMT3 also increased the transcriptional activity of NR1H3 by directly binding with NR1H3 in a methylation-independent manner |
|
UFM1 could suppress foam cell formation via the NR1H3-dependent pathway |
|
AJUBA binds to the hinge and the ligand binding domains of NR1H3 via its C-terminal tandem LIM motifs and enhances NR1H3 target gene expression in liver cells |
|
OSBPL2 binds to liver X receptor (NR1H3) and is required for nuclear NR1H3 expression |
|
CRTC1 directly interferes with the expression of genes regulated by lipogenic transcription factors, most prominently liver x receptor alpha (NR1H3) |
|
EEPD1 is a novel NR1H2, NR1H3-regulated gene in macrophages and likely it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1 |
|
SLC2A5 is regulated by NR1H3 |