basic FUNCTION
| acting as a tissue specific cofactor for RXRA, controlling lipid-inducible expression of APOE in macrophages and adipocytes |
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promoting cholesterol efflux into intestinal lumen via the ABCA1 transporter |
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coactivating CYP7A1 |
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acting as a steroid and thyroid hormone receptor |
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acting as a transcription coactivator |
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nuclear oxysterol receptors with established roles in cholesterol, lipid, and carbohydrate metabolism |
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increases the transcription of genes involved in cholesterol efflux and disposal, such as ABCA1 (ATP-binding cassette transporter A1) |
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NR1H2, NR1H3 are negative regulators of cardiac growth and inflammation via suppressing NF-kappaB signalling in cardiomyocytes |
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induces the transcription of genes that protect cells from cholesterol overload  |
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coactivator-binding surface of NR1H3, but not that of RXRA, is critically important for physical and functional interactions with NCOA1  |
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new role for NR1H3 in phospholipid homeostasis ( |
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NR1H2 and NR1H3 play a crucial role in control of insulin production and secretion in pancreatic beta-cells ( |
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potentially NR1H2 as well as NR1H3 could play a crucial role in the regulation of energy homeostasis  |
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NR1H2, NR1H3 play central roles in the transcriptional control of lipid metabolism  |
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NR1H3 (liver X receptor) and PPARA are nuclear receptors that control the expression of genes involved in glucose and lipid homoeostasis  |
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can act as an important inhibitor of TNFSF11-mediated osteoclast differentiation  |
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is a ligand-activated transcription factor and plays an important role in regulation of lipid homoeostasis and inflammation  |
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NR1H3, NR1H4 initiate formation of coated platelets  |