basic FUNCTION
| modulates the apoCIII gene expression by recruiting different transcription co-activator or co-repressor |
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heme-binding nuclear hormone receptor that represses a broad spectrum of target genes involved in regulating metabolism, the circadian cycle, and proinflammatory responses |
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NR1D1, NR1D2 are major regulators of both clock function and metabolism, displaying a level of subtype collaboration that is unusual among nuclear receptors but common among core clock proteins |
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dual inhibition of NR1D2 and autophagy is an effective strategy for eliciting cytotoxicity in cancer cells |
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plays an unexpected role in sustaining cancer cell survival when the autophagy flux is compromised |
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NR1D1 and NR1D2 are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes |
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NR1D1, NR1D2 may be involved in the repression of orexinergic gene expression |