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FLASH GENE
Symbol NR1D2 contributors: mct/npt - updated : 17-02-2017
HGNC name nuclear receptor subfamily 1, group D, member 2
HGNC id 7963
Location 3p24.2      Physical location : 23.986.750 - 24.022.109
Synonym name
  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog beta
  • Rev-erb-beta
  • orphan nuclear hormone receptor BD73
  • Synonym symbol(s) ERBAB, BD73, EAR-1r, HZF2, RVR, REVERBB , Rev-erb-beta
    DNA
    TYPE functioning gene
    STRUCTURE 35.36 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - RARB - THRB THRB - NR1D2 - cen
    Authors Koh (99)
    Physical map
    FLJ25200 3p24.3 hypothetical protein FLJ25200 RAB5A 3p24-p22 RAB5A, member RAS oncogene family LOC391517 3 similar to Heat shock cognate 71 kDa protein FLJ25449 3p24.3 hypothetical protein MGC27069 PCAF 3p24 p300/CBP-associated factor LOC151648 3p24.3 hypothetical protein BC001339 LOC391518 3 hypothetical gene supported by X74864 FLJ22419 3p24.3 hypothetical protein FLJ22419 LOC389099 3 similar to RIKEN cDNA B830010L13 gene HMG1L5 3p24 high-mobility group (nonhistone chromosomal) protein 1-like 5 LOC391519 3 similar to SALL4B FLJ25157 3p24.2 hypothetical protein FLJ25157 UBE2E1 3p24.1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) KBRAS1 3p24.1 I-kappa-B-interacting Ras-like protein 1 RPL15 3p12-p11.2 ribosomal protein L15 NR1D2 3p24.3-p24.2 nuclear receptor subfamily 1, group D, member 2 LOC391520 3 similar to nucleolar phosphoprotein B23.2 - rat THRB 3p24 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) LOC285324 3p24.1 similar to Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein) LOC391521 3 similar to Cofilin, non-muscle isoform LOC51036 3p24 retinoic acid receptor-beta associated open reading frame RARB 3p24.3 retinoic acid receptor, beta TOP2B 3p24 topoisomerase (DNA) II beta 180kDa LOC391522 3 similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) NGLY1 3p24.1 N-glycanase 1 LOC246135 3p24.1 TBP-associated factor 9-like pseudogene FLJ12409 3p24.1 hypothetical protein FLJ12409 FLJ20604 3p24.1 hypothetical protein FLJ20604 LOC285326 3p24.1 hypothetical protein LOC285326 LOC391523 3 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) VENTX2P4 3p24.1 VENT-like homeobox 2 pseudogene 4 LRP15 3p24 hypothetical protein LRP15 FLJ32685 3p24.1 hypothetical protein FLJ32685 SLC4A7 3p22 solute carrier family 4, sodium bicarbonate cotransporter, member 7 LOC285321 3p23 similar to tropomyosin 4 EOMES 3p21.3-p21.2 eomesodermin homolog (Xenopus laevis)
    regionally located in a duplicated region including THRB and RARB in a region paralog to a region of chromosome 17q11.12 including THRA, NR1D1, RARA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5268 64.6 579 - 2014 24872411
    8 - 5066 - 504 - 2014 24872411
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarybladder   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • nuclear hormone receptor family
  • NR1 subfamily
  • CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • modulates the apoCIII gene expression by recruiting different transcription co-activator or co-repressor
  • heme-binding nuclear hormone receptor that represses a broad spectrum of target genes involved in regulating metabolism, the circadian cycle, and proinflammatory responses
  • NR1D1, NR1D2 are major regulators of both clock function and metabolism, displaying a level of subtype collaboration that is unusual among nuclear receptors but common among core clock proteins
  • dual inhibition of NR1D2 and autophagy is an effective strategy for eliciting cytotoxicity in cancer cells
  • plays an unexpected role in sustaining cancer cell survival when the autophagy flux is compromised
  • NR1D1 and NR1D2 are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes
  • NR1D1, NR1D2 may be involved in the repression of orexinergic gene expression
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heme receptor
  • recruits HTATIP and HDAC1 to regulate apolipoprotein CIII promoter
  • has the potential to activate gene expression, and is a positive regulator of SREBF1, a regulator of lipogenesis
  • oxidative stress leads likely to oxidation of cysteine(s), thus releasing heme from NR1D2 and altering its transcriptional activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rev-Erbb-deficient mice present with increased orexinergic transcripts