basic FUNCTION
| acting as an orphan nuclear (steroid/thyroid/retinoid) receptor |
|
potential negative regulator of receptor dependent signaling pathways |
|
regulator of beta acid synthesis |
|
being an important component of the feedback regulatory cascade controling the conversion of cholesterol to bile acids |
|
specifically inhibiting transactivation of the nuclear receptor with whom it interacts |
|
acting as a steroid hormone receptor |
|
acting as a transcription corepressor |
|
playing an essential role in negative regulation of immune cell activity |
|
having an inhibitory effect on insulin activation of hepatic fatty acid synthesis which constitutes a mechanism that would explain the beneficial effect of FGF19 on metabolic syndrome  |
|
having a role in mediating the reduction in lipogenic enzyme expression caused by FGF19  |
|
inhibits apoptosis during the monocytic differentiation by inducing CDKN1A and prolongs a cellular survival of differentiating monocytes through the transcriptional regulation of target genes of cell survival and differentiation  |
|
nuclear receptor that decreases the expression of Gli target genes by repressing the transcriptional activity of GLI1 and inhibiting its nuclear localization  |
|
can play a negative role in Hedgehog/GLI1 signaling  |
|
recruits SIRT1 and utilizes SIRT1 deacetylase activity to inhibit NR5A2 mediated transcriptional activation  |