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FLASH GENE
Symbol NQO2 contributors: mct - updated : 07-03-2008
HGNC name NAD(P)H dehydrogenase, quinone 2
HGNC id 7856
Location 6p25-p24.3      Physical location : 3.000.066 - 3.019.994
Synonym name NAD(P)H menadione oxidoreductase 2, dioxin-inducible
Synonym symbol(s) NMOR2, DHQV, DIA6, QR2
EC.number 1.6.99.2
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC285770 6p25.2 similar to FLJ00254 protein C6orf195 6p25.2 chromosome 6 open reading frame 195 LOC340156 6p25.2 hypothetical protein LOC340156 WRNIP1 6p24.3 Werner helicase interacting protein 1 SERPINB1 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 SERPINB9 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 SERPINB6 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 NQO2 6p25-p24.3 NAD(P)H dehydrogenase, quinone 2 LOC391864 6 similar to HIV TAT specific factor 1; cofactor required for Tat activation of HIV-1 transcription LOC221754 6p25.2 similar to dJ40E16.3 (novel gene similar to D. melanogaster CG5327 ) RIPK1 6p25.3-p24.1 receptor (TNFRSF)-interacting serine-threonine kinase 1 BPHL 6p25 biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) TUBB 6p21.3 tubulin, beta polypeptide MGC8685 6p25 tubulin, beta polypeptide paralog LOC389362 6 LOC389362 C6orf85 6p25.2 chromosome 6 open reading frame 85 DKFZP434F011 6p25.2-p25.1 ion transporter protein C6orf145 6p25.1 chromosome 6 open reading frame 145 D6S2654E 6pter DNA segment on chromosome 6(unique) 2654 expressed sequence LOC389363 6 hypothetical gene supported by AF118652; NM_006541 PRPF4B 6p24.2 PRP4 pre-mRNA processing factor 4 homolog B (yeast) C6orf146 6p25.1 chromosome 6 open reading frame 146
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1139 - 231 - Jamieson (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Endocrineparathyroid   highly
Reproductivefemale systemuteruscervix highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a specific metal binding site, which is not present in NQO1
  • two histidine nitrogens, one cysteine thiol, and a main chain carbonyl group are involved in metal coordination
  • conjugated FlavoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nqo2
    intraspecies homolog to NQO1
    Homologene
    FAMILY NAD(P)H dehydrogenase (quinone) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzes the two-electron reduction of menadione via the oxidation of N-alkylated or N-ribosylated nicotinamides
  • dihydronicotinamide riboside dependent oxidoreductase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinoma
    Susceptibility to schizophrenia
    Variant & Polymorphism insertion/deletion deletion of the 29 base pair sequence in the promoter may confer susceptibility to a certain form of schizophrenia
    Candidate gene
    Marker
    Therapy target
  • therapeutic target in ovarian carcinoma, because the addition of the nonbiogenic electron donor dihydronicotinamide riboside (NRH) selectively potentiates the bioactivation of the alkylating agent tretazicar
  • potential target of the quinoline antimalarial compounds
  • ANIMAL & CELL MODELS