basic FUNCTION
| involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis |
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may be involved in nitric oxide biosynthesis, response to toxin, synaptic transmission, cholinergic, xenobiotic metabolism |
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plays a role in suppressing inflammatory response and in attenuation of macrophage migration induced by LPS |
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belongs to the phase II detoxifying enzymes that are induced to protect against electrophilic insults, oxidative stress, and ionizing radiation |
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original role in the regulation of mRNA translation via the control of EIF4GI stability by the proteasome  |
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rescue proteins containing intrinsically unstructured domains, such as TP53 and TP73, from degradation by the 20S proteasome  |
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FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones  |
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plays a key role in suppressing ionizing radiation (IR)-induced centrosome amplification and aneuploidy through a direct interaction with Aurora-A  |
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xenobiotic metabolizing enzyme that detoxifies chemical stressors and antioxidants, providing cytoprotection in normal tissues  |