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FLASH GENE
Symbol NPSR1 contributors: mct - updated : 26-06-2006
HGNC name neuropeptide S receptor 1
HGNC id 23631
Location 7p14.3      Physical location : 34.697.896 - 34.917.944
Synonym name
  • vasopressin receptor-related receptor 1
  • G protein-coupled receptor for asthma susceptibility
  • G protein-coupled receptor 154
  • Synonym symbol(s) PGR14 , GPRA, VRR1, GPR154, ASRT2
    DNA
    TYPE functioning gene
    STRUCTURE 220.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1567 - 371 in the epithelia of several organs including bronchi and gastrointestinal tract Laitinen, Vendelin
    - - 1410 - 377 asthmatic smooth muscle, ubiquitous Laitinen, Vendelin
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Gpr154
    Homologene
    FAMILY G-protein coupled receptor 1 family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor for arginine vasopressin
  • mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system
  • involved in social memory formation
  • upregulated in macrophages after antigen challenge and capable of inducing phagocytosis of unopsonized bacteria
  • might have functional relevance in modulating asthma by increased expression levels in the relevant tissues under diseased state and by potential inhibitory effect of GPRAA activation on cell growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    members of a new pathway for the development of asthmatic and allergic disorders
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    upregulated in the airways of asthma patients
    Susceptibility to asthma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS