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FLASH GENE
Symbol NPR3 contributors: mct/npt - updated : 16-01-2024
HGNC name natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
HGNC id 7945
Corresponding disease
BOMOS Boudin-Mortier syndrome
Location 5p13.3      Physical location : 32.711.664 - 32.787.252
Synonym name
  • atrial natriuretic peptide C-type receptor
  • atrial natriuretic peptide clearance receptor precursor
  • guanylate cyclase C
  • Synonym symbol(s) ANPRC, GUCY2B, NPRC, ANP-C, CNPR, ANP-C, BOMOS, C5orf23, NPR-C, FLJ14054, MGC22189
    EC.number 4.6.1.2.
    DNA
    TYPE functioning gene
    STRUCTURE 100.85 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 7454 - 540 - 2023 37543430
    8 - 6294 - 301 - 2023 37543430
    8 - 6367 - 325 - 2023 37543430
    8 - 6364 - 324 - 2023 37543430
    7 - 6244 - 284 - 2023 37543430
    8 - 7457 - 541 - 2023 37543430
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervousnerve   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in the dorsal horn of the embryonic spinal cord (Schmidt 2009)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one transmembrane segment (1TM) and
  • an intracellular domain, without guanylate cyclase activity
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • ANF receptor family, natriuretic peptides family
  • CATEGORY enzyme , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system
  • playing a role for in the regulation of glucagon secretion from human alpha cells (Burgess 2009)
  • NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF, which are regulators of apoptosis
  • anti-apoptosis role of NPR3 in protecting cardiomyocytes suggesting molecular link between natriuretic peptides (NPs) system and programmed cell death
  • NPR3 lacks the guanylate cyclase activity of NPR1 and NPR2 and is reportedly coupled to Gi-dependent signaling
  • plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor
  • regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein could interact with OSTN (modulating NPR3 actions on the skeleton) (Moffatt 2007)
  • OSTN binds to NPR3 competitively with NPPA and may affect NPPA concentrations in a local or systemic manner
  • role of NPR3 in anti-apoptosis via the breast cancer type 1 susceptibility protein (BRCA1) and TNF
  • OSTN binds to natriuretic peptide receptor 3 (NPR3) in periosteal osteoprogenitors, thereby preventing NPR3-mediated clearance of NPPC and consequently facilitating NPPC-signal-mediated bone growth
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BOMOS
    Susceptibility to cerebrovascular disease
    Variant & Polymorphism other
  • NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • its complete absence, unexpectidly produces skeletal abnormalities in mice
  • continuous infusion of the peptide Ostn, an endogenous ligand of Npr3 secreted by bone and muscle cells, lowered blood pressure in wild-type mice, suggesting that endogenous natriuretic peptides play major roles in the regulation of blood pressure