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Symbol NPR3 contributors: mct/npt - updated : 18-12-2009
HGNC name natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
HGNC id 7945
Location 5p13.3      Physical location : 32.711.664 - 32.787.252
Synonym name
  • atrial natriuretic peptide C-type receptor
  • atrial natriuretic peptide clearance receptor precursor
  • Synonym symbol(s) ANPRC, GUCY2B, NPRC, ANP-C, CNPR
    EC.number 4.6.1.2.
    DNA
    TYPE functioning gene
    STRUCTURE 75.60 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC391773 5 similar to Striatin PGBD3P2 5p13.3 piggyBac transposable element derived 3 pseudogene 2 HPRTP2 5p14-p13.3 hypoxanthine phosphoribosyltransferase pseudogene 2 LOC391774 5 similar to hypothetical protein CDH6 5p15.32-p14.2 cadherin 6, type 2, K-cadherin (fetal kidney) RNASE3L 5p15.1 cadherin 6, type 2, K-cadherin (fetal kidney) FLJ11193 5p13.3 hypothetical protein FLJ11193 PDZK3 5p13.2 PDZ domain containing 3 GOLPH3 5p14.1 golgi phosphoprotein 3 (coat-protein) LOC202122 5p13.3 similar to ribosomal protein L27 PIP3AP 5p15.33 phosphatidylinositol-3-phosphate associated protein ZFR 5p13.2 zinc finger RNA binding protein LOC391775 5 similar to Chromosome 1 open reading frame 37 PC4 5p13.3 activated RNA polymerase II transcription cofactor 4 NPR3 5p14-p13 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) FLJ14054 5p13.3 hypothetical protein FLJ14054 LOC389278 5 similar to 40S ribosomal protein S8 TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2651 - 540 - Vassalle (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervousnerve   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in the dorsal horn of the embryonic spinal cord (Schmidt 2009)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one transmembrane segment (1TM) and
  • an intracellular domain, without guanylate cyclase activity
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • ANF receptor family, natriuretic peptides family
  • CATEGORY enzyme , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system
  • playing a role for in the regulation of glucagon secretion from human alpha cells (Burgess 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein could interact with OSTN (modulating NPR3 actions on the skeleton) (Moffatt 2007)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Its complete absence,unexpectidly produces skeletal abnormalities in mice