Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NPPC

contributors: mct - updated : 16-01-2024

HGNC name	natriuretic peptide precursor C
HGNC id	7941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SSSH short stature and small hands
Location	2q37.1      Physical location : 232.790.134 - 232.790.959
Synonym name	C-type natriuretic peptide
Synonym symbol(s)	CNP, CNP2

DNA

TYPE	functioning gene
STRUCTURE	0.83 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024409 2 - 381 NP_077720 - 126 - 2020 32268070

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system ovary       Mus musculus   male system seminal vesicles     highly Homo sapiens   male system male genital tract epididymis   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Reproductive granulosa cell Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	osteoblastic cells (rat), expressed in the embryonic central nervous system

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved 17-AAs disulfide-linked ring structure that is required for biological activity (Dickey 2009)

HOMOLOGY

interspecies

homolog to murine C type (CNP) natriuretic peptide precursor C

Homologene

FAMILY

natriuretic peptide family

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	potentially playing a paracrine/autocrine role
	promoting the differentiation and mineralization of osteoblast-like cells
	regulating endochondral bone growth through NPR2
	important regulator of cartilage homeostasis and endochondral bone growth
	might be the relevant factor for activation of NPR2 on sensory axons to affect their branching at the DREZ (dorsal root entry zone) (Schmidt 2009)
	induces a cGMP signaling cascade via its receptor particulate guanylyl cyclase NPR2 which is essential for sensory axon bifurcation at the dorsal root entry zone (DREZ) of the spinal cord (Schmidt 2009)
	NPPB, NPPA, NPPC activate guanylyl cyclase suggesting a potential role in maintaining lens epithelial cell homeostasis (PMID;
	stimulates ovarian follicle development
	NPPC/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles
	in preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2)
	novel role for NPPC/NPR2 in the epididymal epithelium, presumably in context of local water balance
	play critical roles in cartilage homeostasis and endochondral bone formation
	age-related reduction in the serum NPPC concentration was highly correlated with decreased oocyte quality

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cardiovascular , development

text	bone mineralization

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	regulating BGN during a specific time period
	interacting with NPR2 (system important in endochondral ossification, reversing the FGFR3-mediated inhibition of the endochondral ossification)
	induces bifurcation of ingrowing sensory axons via its receptor NPR2 (Schmidt 2009)
	signaling by NPPC through its receptor, natriuretic peptide receptor 2 (NPR2), was found to be essential for meiotic arrest at the late antral stage
	OSTN enhances the abundance of C-type natriuretic peptide (NPPC), thereby promoting cardiomyocyte contractility through protein kinase A and inhibiting fibroblast activation through protein kinase G signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SSSH

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   enhanced NPPC signalling may prevent growth retardation and protect cartilage in patients with inflammatory joint disease reproduction fertility   NPPC supplementation constitutes an alternative therapeutic approach for advanced maternal age-related oocyte deterioration and may improve the overall success rates of clinically assisted reproduction in older women

ANIMAL & CELL MODELS

spermatozoa from Npr2 mutant mice were not attracted by Nppc, preventing fertilization in vivo