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FLASH GENE
Symbol NPLOC4 contributors: npt/mct - updated : 05-12-2008
HGNC name nuclear protein localization 4 homolog (S. cerevisiae)
HGNC id 18261
Location 17qter      Physical location : 79.523.914 - 79.604.138
Synonym name
  • homolog of yeast nuclear protein localization 4
  • nuclear protein localization protein 4 homolog
  • Synonym symbol(s) FLJ20657, KIAA1499, NPL4, FLJ23742
    DNA
    TYPE functioning gene
    STRUCTURE 80.19 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4401 68 608 - Lass (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc coordinating RNA binding domain
  • UFD1L-interacting motifs
  • HOMOLOGY
    interspecies homolog to rattus Npl4 (96 p100)
    Homologene
    FAMILY
  • NPL4 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    basic FUNCTION playing a regulatory role in ERAD (ER-associated degradation)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a stable heterodimer with UFD1L, which in turn binds the ubiquitous p97/VCP ATPase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UFD1L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS