protein
| NPHP1, BCAR1, TNS, FLNA, FLNB, PTK2B |
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interacting with RPGR (RCC1-like domain of RPGR interacts with the N-terminal 316 AAs of NPHP4) |
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NPHP1 and nephrocystin-4 (NPHP4) interact, and NPHP4 negatively regulates tyrosine phosphorylation of NPHP1 |
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negatively regulates PTK2B-induced tyrosine phosphorylation of NPHP1 by controlling the NPHP1/PTK2B interaction |
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would be a negative regulator by antagonizing PTK2B-induced phosphorylation and decreasing the interaction of NPHP1/PACS1 |
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directly interacted with the kinase LATS1 and inhibited LATS1-mediated phosphorylation of the Yes-associated protein (YAP1) and WWTR1, leading to derepression of these protooncogenic transcriptional regulators |
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NPHP4 acts as a potent negative regulator of mammalian Hippo signalling by interacting with the LATS protein kinase and controlling the phosphorylation of the oncogenic transcriptional activator TAZ |
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NPHP4 enhances the level of nuclear NEK8, thereby promoting the TAZ–NEK8 interaction |
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NPHP4, by inhibiting TAZ phosphorylation at the 14-3-3 binding site, leads to the tandem nuclear accumulation of TAZ and NEK8 |
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JADE1 colocalizes with NPHP1 at the transition zone of primary cilia and interacts with NPHP4 |
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NUP62 and the C termini of NPHP4 and IQCB1 interact with KIF17 and thus spatially map to the inner region of the ciliary gating zone |
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B9D1, AHI1, and the N termini of NPHP4 and IQCB1 interact with the transmembrane protein SSTR3 and thus spatially map to the outer region of the ciliary gating zone |