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FLASH GENE
Symbol NPFFR2 contributors: - updated : 06-09-2007
HGNC name neuropeptide FF receptor 2
HGNC id 4525
Location 4q21      Physical location : 72.897.520 - 73.013.918
Synonym name
  • G protein-coupled receptor 74
  • neuropeptide G protein-coupled receptor
  • neuropeptide FF 2
  • Synonym symbol(s) NPGPR, HLWAR77, GPR74, NPFF2
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 116.00 kb     5 Exon(s)
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR within intron 1
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1936 60.27 522 - Cikos, Ankö
  • lacking exon 2
  • encoding for the longer product
  • also called GPR74IA
  • - splicing 1560 48.55 420 only placenta, adipose tissue Cilkos, Ankö
  • lacking exon 1
  • encoding for the shorter product
  • also called GPR74IB
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
     braindiencephalonamygdala  
     braindiencephalonhypothalamus  
    Reproductivefemale systemplacenta  highly
    Skin/Tegumentskin   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   highly
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    interspecies homolog to chimpanzee NPFFR2 (98.47 pc)
    homolog to rattus Npffr2 (78.76 pc)
    homolog to murine Npffr2 (79.76 pc)
    homolog to chicken NPFFR2 (67.40 pc)
    intraspecies homolog to neuropeptide y receptor
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • morphine-modulating peptide playing a role in pain modulation
  • mediating its action by association with G
  • proteins that activate a phosphatidylinositol- calcium second messenger system
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein NPFF receptor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to leanness, due to increased lipolysis
    Variant & Polymorphism other haplotype ATAG, with allele frequency ~4p100 in Scandinavian cohorts, associated with protection against obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS