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FLASH GENE

Symbol

NPFFR1

contributors: np - updated : 17-02-2006

HGNC name	neuropeptide FF receptor 1
HGNC id	17425

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q21-q22      Physical location : 72.014.713 - 72.043.450
Synonym name	G protein-coupled receptor 147
	neuropeptide FF 1
	RFamide-related peptide receptor OT7T022
Synonym symbol(s)	NPFF1, NPFF1R1, OT7T022, FLJ10751, GPR147

DNA

TYPE	functioning gene
STRUCTURE	23.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NPFFR1 4 - 1293 47 430 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous spinal cord         Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Gm236
	homolog to chimpanzee LOC466099

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	neuropeptide receptor activity
	its activation led to intracellular Ca2+ mobilization in a concentration dependent manner
	mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

NPFF receptor

cell & other

REGULATION

activated by

neuropeptide FF

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS