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FLASH GENE
Symbol NPDC1 contributors: - updated : 02-09-2006
HGNC name neural proliferation, differentiation and control, 1
HGNC id 7899
Location 9q34.3      Physical location : 139.933.908 - 139.940.676
Synonym name CAB1, yeast, homolog of
Synonym symbol(s) CAB1, CAB-, CAB-1
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two transcripts (Qu)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary highly
Nervousbraindiencephalonhypothalamus highly
 brainforebraincerebral lobefrontalhighly
 brainforebraincerebral lobetemporalhighly
Reproductivefemale systemuteruscervix highly
 male systemprostate  highly
Visualeyeanterior segmentiris  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage in neural cells when they stop to divide and begin to differentiate
cell lines
fluid/secretion
at STAGE
Text neural cells, in neural cells when they stop to divide and begin to differentiate
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative signal peptide of 34 aminoacids
  • a transmembrane segment
  • a bipartite nuclear localization signal (NLS)
  • a PEST motif (rich in proline, glutamine, serine, and threonine) in the carboxyl terminus targeting the protein for degradation
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Npdc1
    Homologene
    FAMILY NPDC1/CAB-1 family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • transported in vesicles from the Golgi apparatus to the cell membrane and is then likely internalized into endosomes
  • colocalized, at least partially, with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and RAB3 GEP (RAB3 GTP/GDP exchange protein)
  • basic FUNCTION
  • suppressing oncogenic transformation in neural and non neural cells
  • downregulating neural cell proliferation
  • involved in transcriptional regulation
  • involved in the development of several secretion glands
  • acting as a regulator of retinoic acid-mediated events
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the E2F1 transcription factor, D-type cyclins and CDK2
  • cell & other
    REGULATION
    repressed by by the ubiquitin/proteasome system through a PEST degradation motif
    Other regulated by phosphorylation-mediated proteasomal degradation
    regulation by Krox family transcription factors
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS