SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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text
| late endosomes associating with lysosomes and Golgi |
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localized primarily to late endosomes and lysosomes, where it is involved in lipid sorting and vesicular trafficking, and is thought to act as an efflux pump for cholesterol from these compartments |
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within late endosomes and lysosomes, NPC1 and NPC2 proteins are required for the subsequent delivery of cholesterol to other intracellular compartments |
basic FUNCTION
| regulator of intracellular cholesterol trafficking,from late endosome/lysosome to caveolin 1 and 2 compartment such as the trans Golgi network and plasma membrane caveolae |
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putative transmembrane efflux pump |
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may be facilitate endocytic transport, lysosomal cholesterol efflux and fatty acid efflux |
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having functions in regulating lysosomal amine content |
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may facilitate the transport of cholesterol directly between two compartments, late endosomes/lysosomes and distinct regions of the endoplasmic reticulum |
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regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis |
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regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis |
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with NPC2 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo |
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functions independently of NPC2 in late endosome/lysosome retrograde fusion that leads to the creation of hybrid organelles |
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soluble NPC2 and membrane-bound NPC1 are cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol from lysosomes |
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action for NPC1 and NPC2 in mediating cholesterol efflux |
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both NPC1 and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol |
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function of NPC1, NPC2 within lysosomes are linked closely |
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importance of the interaction between NPC1 and NPC2 proteins to accomplish cholesterol delivery from lysosomes into the cytoplasm |
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required for cholesterol efflux from late endosomes and lysosomes |
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possible role of NPC1 in platelet function and formation |
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may play a role in adipocyte processes underlying obesity |
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