Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NOXO1 contributors: mct - updated : 26-01-2011
HGNC name NADPH oxidase organizer 1
HGNC id 19404
Location 16p13.3      Physical location : 2.028.918 - 2.031.440
Synonym name
  • Nox organizer 1
  • regulatory protein P41NOX
  • NADPH oxidase regulatory protein
  • SH3 and PX domain-containing protein 5
  • Synonym symbol(s) P41NOXA, P41NOXB, P41NOXC, MGC20258, SH3PXD5, SNX28, P41NOX
    DNA
    TYPE functioning gene
    STRUCTURE 2.52 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CRAMP1L 16p13.3 Crm, cramped-like (Drosophila) C16orf34 16p13.3 chromosome 16 open reading frame 34 MAPK8IP3 16p13.3 mitogen-activated protein kinase 8 interacting protein 3 NME3 16q13 non-metastatic cells 3, protein expressed in MRPS34 16p13.3 mitochondrial ribosomal protein S34 LOC390668 16 similar to hypothetical protein 6820428D13 SSB3 16p13.3 SPRY domain-containing SOCS box protein SSB-3 NUBP2 16p13.3 nucleotide binding protein 2 (MinD homolog, E. coli) IGFALS 16p13.3 insulin-like growth factor binding protein, acid labile subunit HAGH 16p13.3 hydroxyacyl glutathione hydrolase DKFZP566J2046 16p13.3 hypothetical protein DKFZp566J2046 MGC35212 16p13.3 hypothetical protein MGC35212 LOC342460 16p13.3 similar to c439A6.1 (novel protein similar to heparan sulfate (glucosamine) 3-O-sulfotransferases) SEPX1 16p13.3 selenoprotein X, 1 RPL3L 16p13.3 ribosomal protein L3-like NDUFB10 16p13.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa RPS2 16p13.3 ribosomal protein S2 RNF151 16p13.3 ring finger protein 151 TBL3 16p13.3 transducin (beta)-like 3 NOXO1 16p13.3 NADPH oxidase organizer 1 GFER 16p13.3-p13.12 growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) SYNGR3 16p13 synaptogyrin 3 LOC90850 16p13.3 hypothetical protein LOC90850 SLC9A3R2 16p13.3 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 NTHL1 16p13.3p13.2 nth endonuclease III-like 1 (E. coli) TSC2 16p13.3 tuberous sclerosis 2 PKD1 16p13.3 polycystic kidney disease 1 (autosomal dominant) RFWD1 16p13.3 ring finger and WD repeat domain 1 RAB26 16p13.3 RAB26, member RAS oncogene family CASKIN1 16p13.11 CASK interacting protein 1 GBL 16p13.3 G protein beta subunit-like MGC21830 16p13.3 hypothetical protein MGC21830
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1587 40 370 - 2005 15949904
    also called variant alpha
    8 splicing 1132 40 371 the major mRNA splice form in human colon and fetal liver 2005 15949904
  • also called variant beta
  • activated NOX1 and NOX3
  • 8 splicing 1147 41 376 majority species in testis 2005 15949904
  • also called variant gamma
  • activated NOX1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Reproductivemale systemtestis   
    Urinarybladder    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines adenocarcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PX homologous domain, known to bind inositol lipids
  • isolated tandem SH3 domains binding to CYBA with high affinity, most likely adopting a superSH3 domain conformation
  • a proline-rich region (PRR), participating in activation of superoxide-producing Nox-family NADPH oxidases
  • C-terminal tail can competes for binding to CYBA and thereby contributes to the regulation of superoxide production
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in intracellular signaling cascade
  • activating NOX1
  • binding to membrane lipids through its PX domain
  • with NOXA1, having a role, as well as the binding of Rac1 GTPase, for NOX1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complex consisting of NOX1, ARHGEF7, and NOXO1 is likely to be a critical step in EGF-induced reactive oxygen species generation
  • assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the phosphatidylinositol (PtdIns) lipids PtdIns 3,5-P2, PtdIns 5-P, and PtdIns 4-P
  • interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase
  • cell & other
    REGULATION
    Other regulation of its activity through reversible interactions with CYBA and NOXA1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS