Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NOX5 | contributors: mct/pgu - updated : 17-12-2013 |
HGNC name | NADPH oxidase, EF hand calcium-binding domain 5 |
HGNC id | 14874 |
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Location | 15q23 Physical location : 69.222.838 - 69.349.500 |
Synonym name | NOX5 variant lacking EF hands |
Synonym symbol(s) | NOX5A, NOX5B, MGC149776, MGC149777 |
EC.number | 1.6.3.- |
DNA |
TYPE | functioning gene |
STRUCTURE | 126.66 kb 16 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | octamer |
HOMOLOGY |
Homologene |
FAMILY | NOX family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endoplasmic reticulum | |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | protein kinase C, in addition to its Ca(2+) activation |
by the coordinated phosphorylation of both MAPK and PKC pathways |
Other | regulated by Ca(2+) through intramolecular activation of the C-terminal catalytic domain by the EF-hand-containing N-terminal regulatory domain |
phosphorylation at key AAs facilitates enzyme activation at lower levels of intracellular calcium and may provide an avenue for enzyme activation in response to a greater variety of extracellular stimuli |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |