basic FUNCTION
| involved in growth control in non phagocytic cells |
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pyridine nucleotide dependent superoxide generating |
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acting as a voltage gated proton (H+) channel |
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playing a crucial role in irradiation-induced ROS generation and ROS-associated impairment of salivary gland cells |
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NOX1 mRNA and protein are overexpressed in colon cancer and are strongly correlated with activating mutations in K-Ras |
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mediates oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1 |
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controls the persistence of directed cell migration by a Rho-dependent switch of alpha2/alpha3 integrins |
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mediating role of NOX1-generated reactive oxygen species in cell invasion processes, most notably metalloprotease production and cell motile activity |
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involved in TP53 deacetylation and its activation may activate SIRT1 and inhibit TP53 |
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controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/WNT/CTNNB1 and NOTCH1 signaling |
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plays a role in host defense, cell growth and differentiation, cell migration, and malignant transformation |
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NADPH oxidase homologue which requires the regulatory subunits NOXO1 and NOXA1, as well as the flavocytochrome component CYBA for maximal activity |
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might control autocrine cell growth of liver tumor cells through regulation of the EGFR pathway |
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NOX1 and CYBB play differential roles in different platelet activation pathways and in thrombosis |