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FLASH GENE
Symbol NOX1 contributors: mct - updated : 20-10-2014
HGNC name NADPH oxidase 1
HGNC id 7889
Location Xq22.1      Physical location : 100.098.313 - 100.129.334
Synonym name
  • NADPH oxidase homolog 1
  • NADPH oxidase 1 variant NOH-1L
  • mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)
  • NADH/NADPH mitogenic oxidase subunit P65-MOX
  • Synonym symbol(s) MOX1, NOH1, GP91.2, NOH-1, NOH-1
    EC.number 1.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 31.02 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392507 X similar to HSPC129 protein LOC158656 Xq22.1 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) PCDH19 Xq13.3 protocadherin 19 TNMD Xq21.33-q23 protocadherin 19 TM4SF6 Xq22 transmembrane 4 superfamily member 6 SRPUL Xq21.33-q23 sushi-repeat protein SYTL4 Xq21.33 synaptotagmin-like 4 (granuphilin-a) LOC392508 X similar to Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) CSTF2 Xq22.2-q22.3 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa NOX1 Xq22 NADPH oxidase 1 LOC389877 X similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC347424 Xq22.1 similar to TGF beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1) (HUSSY-29) LOC286453 Xq22.1 similar to dJ341D10.1 (novel protein) LOC392509 X similar to hypothetical protein DKFZp761H079 isoform 1 FLJ12687 Xq22.1 hypothetical protein FLJ12687 FLJ14084 Xq22.1 hypothetical protein FLJ14084 FSHPRH1 Xq22 FSH primary response (LRPR1 homolog, rat) 1 LOC392510 X similar to 14-3-3 protein tau (14-3-3 protein theta) DRP2 Xq22 dystrophin related protein 2 TAF7L Xq22.1 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa TIMM8A Xq22.1 translocase of inner mitochondrial membrane 8 homolog A (yeast) BTK Xq22.1-q22.2 Bruton agammaglobulinemia tyrosine kinase RPL36A Xq26.3-q27.3 ribosomal protein L36a GLA Xq22.11 galactosidase, alpha HNRPH2 Xq21.3-q22 heterogeneous nuclear ribonucleoprotein H2 (H') LOC389878 X LOC389878 MGC40053 Xq22.1 hypothetical protein MGC40053 LOC158948 Xq22.1 protein kinase C, iota pseudogene ALEX1 Xq21.33-q22.2 protein kinase C, iota pseudogene FLJ20811 Xq21.33-q22.3 hypothetical protein FLJ20811 ALEX3 Xq21.33-q22.2 ALEX3 protein ALEX2 Xq21.33-q22.2 ALEX2 protein GKP6 Xq22-q23 glycerol kinase pseudogene 6 NXF5 Xq22 nuclear RNA export factor 5 KIAA1789 Xq21 KIAA1789 protein my048 Xq22.1-q22.3 my048 protein LOC158931 Xq22.1 similar to hypothetical protein MGC15737 LOC340542 Xq22.1 hypothetical protein LOC340542
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 2529 61.8 564 colon, uterus, prostate, colon carcinoma 2000 10615049
    also called NOH-1L
    12 splicing 2382 - 515 - 1999 10485709
    also called NOH-1Lv
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningendothelium  
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    Digestiveepithelial cell Homo sapiens
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines cancer cell lines HepG2, Caco2
    fluid/secretion
    at STAGE
    physiological period fetal
    Text thymus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three identical transmembrane domains
  • a distinct fourth transmembrane domain
  • a short intracellular C terminus
  • HOMOLOGY
    intraspecies paralog to GP91 phox (CYBB)
    Homologene
    FAMILY reactive oxygen species (ROS)-generating NADPH oxidase family
    CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text
  • localization of NADPH oxidase in perivascular nerve fibers
  • localized in the plasma membrane
  • basic FUNCTION
  • involved in growth control in non phagocytic cells
  • pyridine nucleotide dependent superoxide generating
  • acting as a voltage gated proton (H+) channel
  • playing a crucial role in irradiation-induced ROS generation and ROS-associated impairment of salivary gland cells
  • NOX1 mRNA and protein are overexpressed in colon cancer and are strongly correlated with activating mutations in K-Ras
  • mediates oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1
  • controls the persistence of directed cell migration by a Rho-dependent switch of alpha2/alpha3 integrins
  • mediating role of NOX1-generated reactive oxygen species in cell invasion processes, most notably metalloprotease production and cell motile activity
  • involved in TP53 deacetylation and its activation may activate SIRT1 and inhibit TP53
  • controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/WNT/CTNNB1 and NOTCH1 signaling
  • plays a role in host defense, cell growth and differentiation, cell migration, and malignant transformation
  • NADPH oxidase homologue which requires the regulatory subunits NOXO1 and NOXA1, as well as the flavocytochrome component CYBA for maximal activity
  • might control autocrine cell growth of liver tumor cells through regulation of the EGFR pathway
  • NOX1 and CYBB play differential roles in different platelet activation pathways and in thrombosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    a component
  • complex consisting of NOX1, ARHGEF7, and NOXO1 is likely to be a critical step in EGF-induced reactive oxygen species generation
  • assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functionally associates with PDIA4, regulating redox-sensitive signalling pathways in a cellular context
  • RGS2 inhibits STAT3-mediated NOX1 transcription, and can itself be repressed by TLR2
  • cell & other
    REGULATION
    activated by NOXO1
    induced by gamma-ray irradiation
    Other regulated by NFkappaB (NF-kappaB is an essential regulator of NOX1- and NOX4-containing NADPH oxidase in smooth muscle cells)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression of NOX1 could contribute to the development of colorectal cancer
    tumoral       loss of function
    NOX1 and CYBB deficiency impairs macrophage differentiation and the occurrence of M2-type tumor-associated macrophages (TAMs) during tumor development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • NOX1 modulation might represent a novel strategy for colorectal cancer
  • SystemTypeDisorderPubmed
    cancerdigestivecolon
    NOX1 modulation might represent a novel strategy for colorectal cancer
    ANIMAL & CELL MODELS