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FLASH GENE
Symbol NOVA2 contributors: mct - updated : 20-01-2014
HGNC name neuro-oncological ventral antigen 2
HGNC id 7887
Location 19q13.32      Physical location : 46.442.770 - 46.476.657
Synonym name
  • neuro-oncological ventral antigen 3
  • astrocytic NOVA1-like gene
  • Synonym symbol(s) ANOVA, NOVA3
    DNA
    TYPE functioning gene
    STRUCTURE 33.89 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FOSB 19q13.3 FBJ murine osteosarcoma viral oncogene homolog B RTN2 19q13.3 reticulon 2 VASP 19q13.2-q13.3 vasodilator-stimulated phosphoprotein FLJ40125 19q13.32 hypothetical protein FLJ40125 OPA3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) GPR4 19q13.3 G protein-coupled receptor 4 EML2 19q13.32 echinoderm microtubule associated protein like 2 GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin FOXA3 19q13.2-q13.4 forkhead box A3 IRF2BP1 19q13.32 interferon regulatory factor 2 binding protein 1 LOC339344 19q13.32 hypothetical protein LOC339344 NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein LOC339346 19q13.33 similar to histidine secretory acid phosphatase LOC388555 19 similar to RPRC483 LOC126052 19q13.33 TGFB-induced factor (TALE family homeobox) pseudogene LOC147920 19q13.33 similar to VPRI645 LOC390944 19 similar to 60S ribosomal protein L12 UNQ644 19q13.33 APRG644 HIF3A 19q13.33 hypoxia inducible factor 3, alpha subunit PPP5C 19q13.3 protein phosphatase 5, catalytic subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1885 - 492 - 1997 10735272
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Nervousbrain    
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    RNA binding protein with three K homology (KH) motifs
    HOMOLOGY
    interspecies ortholog to murine Nova2
    homolog to Drosophila ps
    intraspecies homolog to NOVA1
    Homologene
    FAMILY
    CATEGORY RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating RNA splicing or metabolism in a specific subset of developing neurons
  • regulating functional and structural synaptic changes that underlie synaptic plasticity
  • NOVA1, NOVA2 regulate neuronal pre-messenger RNA splicing by directly binding to RNA
  • regulating splicing of RNAs encoding synaptic functions
  • playing specific regulatory role in controlling a clinically significant alternative splicing of SCN1A
  • neuron-specific RNA binding protein that contributes to neuronal migration by regulating alternative splicing of DAB1
  • neuron-specific RNA-binding protein that regulates neuronal migration in late-generated cortical and Purkinje neurons
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NOVA1 and NOVA2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) AGRN, involved in synapse formation at the neuromuscular junction (NMJ)
  • regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration
  • NOVA2 controls alternative splicing in CACNA1A and CACNA1B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS