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FLASH GENE
Symbol NOVA2 contributors: mct - updated : 24-08-2020
HGNC name neuro-oncological ventral antigen 2
HGNC id 7887
Corresponding disease
NEDASB neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities
Location 19q13.32      Physical location : 46.442.770 - 46.476.657
Synonym name
  • neuro-oncological ventral antigen 3
  • astrocytic NOVA1-like gene
  • Synonym symbol(s) ANOVA, NOVA3, NEDASB, NOVA-2
    DNA
    TYPE functioning gene
    STRUCTURE 33.89 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1885 - 492 - 1997 10735272
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Nervousbrainforebraincerebral cortex   Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    RNA binding protein with three K homology (KH) motifs
    HOMOLOGY
    interspecies ortholog to murine Nova2
    homolog to Drosophila ps
    intraspecies homolog to NOVA1
    Homologene
    FAMILY angioneurins family
    CATEGORY RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulating RNA splicing or metabolism in a specific subset of developing neurons
  • regulating functional and structural synaptic changes that underlie synaptic plasticity
  • NOVA1, NOVA2 regulate neuronal pre-messenger RNA splicing by directly binding to RNA
  • regulating splicing of RNAs encoding synaptic functions
  • playing specific regulatory role in controlling a clinically significant alternative splicing of SCN1A
  • neuron-specific RNA binding protein that contributes to neuronal migration by regulating alternative splicing of DAB1
  • neuron-specific RNA-binding protein that regulates neuronal migration in late-generated cortical and Purkinje neurons
  • NOVA2 functions as an alternative splicing (AS) regulator in angiogenesis and is a novel member of the 'angioneurins' family
  • is required for, respectively, development of laminar structure, motor coordination, and synapse formation
  • NOVA1 and NOVA2 are novel beta-catenin RNA-binding proteins
  • important role of NOVA2 as an axonal pathfinder modifier during cortical development
  • regulates a series of alternative splicing (AS) events linked to neurite outgrowth and axonal projections in human neural stem cells (hNSCs)
  • regulates alternative splicing (AS) of different genes encoding proteins involved in signal transduction and cytoskeleton organization, playing a role in neuronal differentiation and migration
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NOVA1 and NOVA2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) AGRN, involved in synapse formation at the neuromuscular junction (NMJ)
  • regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration
  • NOVA2 controls alternative splicing in CACNA1A and CACNA1B
  • regulates alternative splicing events of a series of axon guidance related genes during cortical development
  • NOVA2 integrated splicing decisions in order to regulate PPPARG and E2F1 activities
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDASB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic targets in breast cancer
    ANIMAL & CELL MODELS