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FLASH GENE
Symbol NOVA1 contributors: mct - updated : 31-08-2016
HGNC name neuro-oncological ventral antigen 1
HGNC id 7886
Location 14q12      Physical location : 26.915.089 - 27.066.960
Genatlas name neuro-oncological ventral antigen 1 identified using antisera from patients with breast, and with a paraneoplastic neurologic disorder cancer, involving subcortical motor system characterized by paraneoplastic opsoclonus myoclonus ataxia
Synonym name
  • paraneoplastic Ri antigen
  • ventral neuron-specific protein 1
    • Synonym symbol(s) NOVA-1, NOVA
    DNA
    TYPE functioning gene
    STRUCTURE 151.87 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • putative regulatory AU-rich elements (ARE) in its highly conserved 3prime-untranslated region
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3918 52.1 507 brain 1997 9154818
    including an in-frame 9 bp motif exactly at the terminus of RiTE1 and the alternatively spliced 72 bp exon H, precisely at the 5' boundary of RiTE2.
    4 splicing 3846 - 483 cerebellum and brainstem 1997 9154818
    including an in-frame 9 bp motif exactly at the terminus of RiTE1 and lacking the alternatively spliced 72 bp exon H
    5 splicing 1210 - 181 tumor 1997 9154818
  • including an in-frame deletion of 9 bp exactly at the terminus of RiTE1 and the in-frame alternatively spliced 72 bp exon H
  • diverging to go out of reading frame, producing a truncated protein (following exon H)
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas     Homo sapiens
    Nervousbrainbasal nuclei    Rattus norvegicus
     braindiencephalonhypothalamus   Rattus norvegicus
     brainlimbic systemhippocampus   Rattus norvegicus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		RNA binding protein with three K homology (KH) motifs
    HOMOLOGY
    interspecies ortholog to murine Nova1
    homolog to Drosophila ps
    homolog to Celegans F26B1.2
    Homologene
    FAMILY Nova family of paraneoplasic disease antigens
    CATEGORY RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • regulating RNA splicing or metabolism in developing neurons
  • regulating functional and structural synaptic changes
  • regulating splicing of RNAs encoding synaptic function that underlie synaptic plasticity
  • NOVA1, NOVA2 regulate neuronal pre-messenger RNA splicing by directly binding to RNA
  • neuron-specific splicing factor that controls the alternative processing of a wide array of mRNAs important for synaptic activity
  • essential for the proper development of the mammalian motor system and for the survival of motoneurons
  • might mediate neuronal responsiveness
  • is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors
  • is a master regulator of alternative splicing in pancreatic beta cells
  • NOVA1 and NOVA2 are novel beta-catenin RNA-binding proteins
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • is the first factors affecting the expression and activity of NOVA1 and, consequently, is major candidat for the physiological modulation of NOVA1-dependent processing of pre-mRNAs in neurons
  • NOVA1 and NOVA2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) AGRN, involved in synapse formation at the neuromuscular junction (NMJ)
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • PTBP1 interacts with TERT pre-mRNA in a NOVA1 dependent fashion
    • cell & other
    REGULATION
    inhibited by paraneoplastic antibodies
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric tumor cells was associated with tumor progression and poor prognosis
    tumoral       gain of function
    may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may act as a prognostic marker for poor outcome and high recurrence in hepatocellular carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic targets in breast cancer
    ANIMAL & CELL MODELS
    Nova1-deficient mice (Jensen,2000)