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FLASH GENE
Symbol NOSTRIN contributors: mct - updated : 13-05-2020
HGNC name nitric oxide synthase trafficker
HGNC id 20203
Location 2q24.3      Physical location : 169.643.048 - 169.721.849
Synonym name
  • endothelial nitric oxide synthase (ENOS) traffic inducer
  • nitric oxide synthase traffic inducer
  • ortholog of mouse disabled 2 interacting proein 2
  • Synonym symbol(s) MGC20702, DALP2
    DNA
    TYPE functioning gene
    STRUCTURE 78.98 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2819 - 563 - 2009 18980613
    15 - 1854 48.8 428 mainly localizes to the cell nucleus 2009 18980613
  • NOSTRINbeta lacking the first 78 amino acids of full-length NOSTRIN (NOSTRINalpha), and thus a substantial part of its F-BAR domain
  • nuclear import of NOSTRINbeta depends on two nuclear localization signals (aa 32-36: KKRK and aa 57-61: KAKKK)
  • 15 - 1863 - 478 - 2009 18980613
    16 - 2075 57.6 506 conspicuously absent from the nucleus 2009 18980613
    NOSTRINalpha
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     liver   moderately
     salivary gland   highly
    Endocrineplacenta     Homo sapiens
    Nervousnerve   lowly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal FCH domain
  • a BAR domain
  • C-terminal SH3 domain interacting with the proline rich domain of DAB2 which had been identified to possess a transcriptional activation function, SH3 domain involved in the NOSTRIN-TRAF6 interaction and required for NOSTRIN-induced down-regulation of endothelial cell proteins
  • HOMOLOGY
    interspecies homolog to murine Daip2
    Homologene
    FAMILY endophilin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • in trophoblast cells of the placenta, predominantly in trophoblast giant cells (TGC)
  • basic FUNCTION
  • modulates nitric oxide (NO) release and subcellular distribution of endothelial NOS
  • triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellulars structures, there by attenuating ENOS-dependent NO production
  • may play a regulatory role in synaptic vesicle recycling
  • controls activity, trafficking, and targeting of nitric oxide synthase
  • during caveolar trafficking, NOSTRIN functions as an adaptor to recruit mediators such as dynamin-2 essential for membrane fission
  • strong synergism between NOSTRIN and TRIP10 functions
  • F-BAR protein NO synthase traffic inducer (NOSTRIN) is an interaction partner of endothelial nitric oxide (NO) synthase and modulates its subcellular localization
  • is a potential negative regulator of disease aggressiveness, which may be targeted for designing improved treatment strategy in Pancreatic ductal adenocarcinoma (PDAC)
  • is a pleiotropic regulator of endothelial cell function and signaling
  • NOSTRIN potentiates trophoblast differentiation towards trophoblast giant cells (TGC) trajectory that is critical for hemochorial placentation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding ENOS
  • with SYNJ1 and DNM1
  • directly binds to CAV1, a well-established inhibitor of endothelial nitric-oxide synthase (eNOS)
  • nuclear NOSTRINbeta may negatively regulate transcription of the NOSTRIN gene
  • is required for FGF2 dependent activation of RAC1 in primary endothelial cells and the angiogenic response to FGF2
  • cooperative functions of the two F-BAR proteins TRIP10 and NOSTRIN in the regulation of CDH1 in epithelial morphogenesis
  • NOSTRIN is crucial for the localization and function of the CHRM3 and NO production
  • NOSTRIN interacted directly with TRAF6, leading to the suppression of NFKB1 activity and inhibition of AKT1 activation via phosphorylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    may be targeted for designing improved treatment strategy in Pancreatic ductal adenocarcinoma (PDAC)
    ANIMAL & CELL MODELS