basic FUNCTION
| modulates nitric oxide (NO) release and subcellular distribution of endothelial NOS |
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triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellulars structures, there by attenuating ENOS-dependent NO production |
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may play a regulatory role in synaptic vesicle recycling |
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controls activity, trafficking, and targeting of nitric oxide synthase |
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during caveolar trafficking, NOSTRIN functions as an adaptor to recruit mediators such as dynamin-2 essential for membrane fission |
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strong synergism between NOSTRIN and TRIP10 functions |
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F-BAR protein NO synthase traffic inducer (NOSTRIN) is an interaction partner of endothelial nitric oxide (NO) synthase and modulates its subcellular localization |
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is a potential negative regulator of disease aggressiveness, which may be targeted for designing improved treatment strategy in Pancreatic ductal adenocarcinoma (PDAC) |
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is a pleiotropic regulator of endothelial cell function and signaling |
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NOSTRIN potentiates trophoblast differentiation towards trophoblast giant cells (TGC) trajectory that is critical for hemochorial placentation |