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FLASH GENE
Symbol NOSIP contributors: KTN/npt - updated : 23-02-2009
HGNC name nitric oxide synthase interacting protein
HGNC id 17946
Location 19q13.33      Physical location : 50.058.969 - 50.083.803
Synonym name
  • CGI-25 protein
  • eNOS interacting protein
  • Synonym symbol(s) CGI-25
    DNA
    TYPE functioning gene
    STRUCTURE 24.84 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D19S879 - D19S604 - NOSIP - D19S867 - D19S866 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1116 33 301 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineplacenta    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain, C3HC4 type
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Nosip (91.7 pc)
    homolog to murine Nosip (90.7 pc)
    Homologene
    FAMILY
  • NOSIP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text translocated from nucleus to cytoplasm in the G2 phase of the cell cycle
    basic FUNCTION
  • negatively regulating nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity
  • promoting translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NOS1 and NOS3
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS