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FLASH GENE
Symbol NOSIP contributors: KTN/npt - updated : 23-02-2009
HGNC name nitric oxide synthase interacting protein
HGNC id 17946
Location 19q13.33      Physical location : 50.058.969 - 50.083.803
Synonym name
  • CGI-25 protein
  • eNOS interacting protein
  • Synonym symbol(s) CGI-25
    DNA
    TYPE functioning gene
    STRUCTURE 24.84 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D19S879 - D19S604 - NOSIP - D19S867 - D19S866 - qter
    Authors UCSC (2009)
    Physical map
    LIN7B 19q13.3 lin-7 homolog B (C. elegans) FLJ10490 19q13.33 hypothetical protein FLJ10490 PPFIA3 19q13.3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 HRC 19q13.3 histidine rich calcium binding protein TRPM4 19q13.32 transient receptor potential cation channel, subfamily M, member 4 NTT5 19q13.1-q13.4 transient receptor potential cation channel, subfamily M, member 4 CD37 19q13.3 CD37 antigen DKKL1-pending 19q13.33 soggy-1 gene TEAD2 19q13.3 TEA domain family member 2 FLJ32658 19q13.33 hypothetical protein FLJ32658 TIP39 19q13.33 tuberoinfundibular 39 residue protein precursor LOC390955 19 similar to ENSANGP00000004655 SLC17A7 19q13 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 FLJ20643 19q13.33 hypothetical protein FLJ20643 MGC10204 19q13.33 hypothetical protein MGC10204 FLT3LG 19q13.3 fms-related tyrosine kinase 3 ligand RPL13A 19q13.4 ribosomal protein L13a RPS11 19q13.3 ribosomal protein S11 FCGRT 19q13.3 Fc fragment of IgG, receptor, transporter, alpha RCN3 19q13.33 reticulocalbin 3, EF-hand calcium binding domain NOSIP 19q13.3 nitric oxide synthase interacting protein PRRG2 19q13.33 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 KIAA1205 19q13.33 KIAA1205 RRAS 19q13.3-q13.4 related RAS viral (r-ras) oncogene homolog SR-A1 19q13.3-q13.4 serine arginine-rich pre-mRNA splicing factor SR-A1 IRF3 19q13.3 interferon regulatory factor 3 BCL2L12 19q13.3 BCL2-like 12 (proline rich) HRMT1L2 19q13-3 HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) LOC199800 19q13.33 hypothetical protein LOC199800 CPT1C 19q13.33 hypothetical protein LOC199800 LOC388556 19 hypothetical gene supported by NM_001013 TSKS 19q13.3 hypothetical gene supported by NM_001013 AP2A1 19q13.3 adaptor-related protein complex 2, alpha 1 subunit FLJ22688 19q13.33 hypothetical protein FLJ22688 TCBAP0758 19q13.3 hypothetical protein TCBAP0758 PTOV1 19q13.33 prostate tumor over expressed gene 1 PNKP 19q13.3-q13.4 polynucleotide kinase 3'-phosphatase MGC2865 19q13.33 hypothetical protein MGC2865 FLJ12168 IL4I1 19q13.3-q13.4 interleukin 4 induced 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1116 33 301 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineplacenta    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain, C3HC4 type
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Nosip (91.7 pc)
    homolog to murine Nosip (90.7 pc)
    Homologene
    FAMILY
  • NOSIP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text translocated from nucleus to cytoplasm in the G2 phase of the cell cycle
    basic FUNCTION
  • negatively regulating nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity
  • promoting translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NOS1 and NOS3
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS