Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NOP58 contributors: mct - updated : 26-08-2014
Location 2q33.1      Physical location : 203.130.514 - 203.168.382
Genatlas name nucleolar protein NOP5/NOP58
Synonym name nucleolar protein NOP5
Synonym symbol(s) HSPC120, NOP5, NOP5/NOP58
DNA
TYPE functioning gene
STRUCTURE 37.87 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 1979 59 529 - 1999 10094313
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative Sno RNA binding domain
  • a highly charged C terminal domain
  • a consensus phosphorylation sites
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Nop5/Nop58
    intraspecies homolog to NOP56
    Homologene
    FAMILY
  • NOP5/NOP56 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • essential nucleolar protein
  • involved in fundamental cellular growth processes
  • NOP56 and NOP58 are required for ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • second common component of the box C+D snoRNPs to be identified and the first to be shown to be required for the stability and for the synthesis of these snoRNAs
  • INTERACTION
    DNA
    RNA binding to the box C/D family of SnoRNAs
    small molecule
    protein
  • RUVBL2, RUVBL1 efficiently bridge interactions between the core box C/D proteins NOP56 or NOP58 and NHP2L1
  • cell & other
    REGULATION
    Other SUMOylation is essential for high-affinity NOP58 binding to snoRNAs
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS