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FLASH GENE

Symbol

NOP10

contributors: mct - updated : 24-06-2021

HGNC name	NOP10 ribonucleoprotein homolog (yeast)
HGNC id	14378

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DKC4 dyskeratosis congenita 4
Location	15q14      Physical location : 34.633.916 - 34.635.362
Synonym name	nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
	homolog of yeast Nop10p
	snoRNP protein NOP10
Synonym symbol(s)	NOP10P, NOLA3, MGC70651, DKCB1

DNA

TYPE	functioning gene
STRUCTURE	1.42 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018648 2 - 507 isoform 1 7.6 64 - 2020 32554502

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine adrenal gland       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage
cell lines	proliferating cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N and C terminal core domains

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae Nop10p

Homologene

FAMILY	H/ACA snoRNP nucleolar protein family
	NOP10 family

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
	intracellular,nucleus,nucleolus
text	dense fibrillar component of nucleole and cajal bodies

basic FUNCTION	playing a role in ribosomal RNA production and pseudouridylation of pre RNAS
	involved in the telomerase complex and telomere maintenance
	embryonic stem cells (ESCs), ubiquitously express NOP10 and DKC1, stabilizing components of telomerase complexes
	is required for ribosome biogenesis and telomere maintenance and plays a key role in carcinogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	telomerase complex, associating with GAR1, NHP2, DKC1, TERC, TERT
	DKC1-NOP10-NHP2 core trimer specifically recognizes H/ACA RNAs (Wang 2004)

INTERACTION

DNA

RNA

small molecule

protein

interaction with TERC (assembles not one but two sets of all four of the H/ACA RNP core proteins, dyskerin, NOP10, NHP2, and GAR1) (Egan 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DKC4

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	High NOP10 expression is a poor prognostic biomarker in Breast cancer and its expression can help in predicting chemotherapy resistance
Therapy target
	System Type Disorder Pubmed cancer reproductive breast potential therapeutic values in various BC subtypes especially in the aggressive TNBC class

ANIMAL & CELL MODELS