| basic FUNCTION
| functioning as a coactivator of androgen receptors that potentiates transcription and possibly splicing |
|
with PSPC1 and SFPQ, may cooperatively regulate androgen receptor-mediated gene transcription  |
|
plays an important role in the regulation of Sox9 function and the formation of paraspeckle bodies during chondrogenesis |
|
acting as a bridge between the CREB/TORC complex and RNA polymerase II (Amelio 2007) |
|
having a functions in recruitment of XRN2 to facilitate pre-mRNA 3' processing and transcription termination (Kaneko 2007) |
|
core paraspeckle proteins |
|
SFPQ/NONO heterodimer was previously found to enhance DNA strand break rejoining |
|
critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing |
|
involved in many nuclear processes including transcription, RNA processing, and retention of hyperedited RNAs |
|
involvement of NONO and SFPQ in DNA double-strand break repair (DSB) and radioresistance |
|
serve as transcriptional cofactor for correct circadian clock function, where it regulate the circadian clock via interaction with PER proteins |
|
important role of NONO, PSPC1, SFPQ within the circadian oscillator |
|
overlapping or redundant roles of NONO, PSPC1, SFPQ as transcriptional cofactors at circadian clock-regulated genes |
|
regulates synaptic transcription and gephyrin scaffold structure |
|
may likely contribute to the regulation of RNA metabolism underlying local regulation of dendritic spine morphology and has a major and unsuspected role in regulating synaptic morphology at a cellular level |
