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FLASH GENE
Symbol NOMO2 contributors: mct/ - updated : 29-05-2006
HGNC name NODAL modulator 2
HGNC id 22652
Location 16p12.3      Physical location : 18.511.182 - 18.573.434
Synonym name
  • pM5 protein, centromeric copy
  • pM5 protein 2
  • Synonym symbol(s) Nomo, PM5
    DNA
    TYPE functioning gene
    STRUCTURE 62.25 kb     32 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D16S3114 - TNFRSF17 - NOMO2 - MYH11 - D16S405 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 3986 - 1267 - 2004 15257293
    31 - 4317 - 1222 - 2004 15257293
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineparathyroid   highly
     thyroid   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text colocalizes with TMEM147 and NCLN in the endoplasmic reticulum (ER)
    basic FUNCTION
  • part of a protein complex that participates in the NODAL signaling pathway during vertebrate development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of Nicalin-NOMO-TMEM147 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TMEM147, Nicalin, and NOMO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS