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FLASH GENE
Symbol NOLC1 contributors: mct - updated : 28-08-2014
HGNC name nucleolar and coiled-body phosphoprotein 1
HGNC id 15608
Location 10q24.32      Physical location : 103.911.932 - 103.923.627
Synonym name
  • nucleolar phosphoprotein p140
  • Synonym symbol(s) NOPP130, NOPP140, KIAA0035, PI30, NS5ATP13
    DNA
    TYPE functioning gene
    STRUCTURE 11.69 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • NFKB1 and CREB positively regulated the NOLC1 promoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    LBX1 10q24 transcription factor similar to D. melanogaster homeodomain protein lady bird late BTRC 10q24-q25 beta-transducin repeat containing POLL 10q23 polymerase (DNA directed), lambda DKFZP566F084 SHFM3 10q24 split hand/foot malformation (ectrodactyly) type 3 FGF8 10q24 fibroblast growth factor 8 (androgen-induced) NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase) KCNIP2 10q24 Kv channel interacting protein 2 FLJ13114 10q24.32 hypothetical protein FLJ13114 HPS6 10q24.32 hypothetical protein FLJ13114 LDB1 10q24-q25 LIM domain binding 1 PRC 10q24.32 PGC-1 related co-activator NOLC1 10q22-q25 nucleolar and coiled-body phosphoprotein 1 ELOVL3 10q24.32 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 PITX3 10q25 paired-like homeodomain transcription factor 3 GBF1 10q24 golgi-specific brefeldin A resistance factor 1 NFKB2 10q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) PSD 10q24 pleckstrin and Sec7 domain protein MGC11279 10q24.32 hypothetical protein MGC11279 MGC2491 FLJ14280 10q24.32 hypothetical protein FLJ14280 FLJ22529 10q24.32-q24.33 hypothetical protein FLJ22529 ACTR1A 10q24 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) SUFU 10q24.32 suppressor of fused homolog (Drosophila) TRIM8 10q24.3 tripartite motif-containing 8 ARL3 10q24.1 ADP-ribosylation factor-like 3 SFXN2 10q24.32 sideroflexin 2 C10orf26 10q24.33 chromosome 10 open reading frame 26 CYP17A1 10q24.3 cytochrome P450, family 17, subfamily A, polypeptide 1 LOC390000 10 similar to Tebp-pending-prov protein C10orf32 10q24.33 chromosome 10 open reading frame 32 CYT19 10q24.33 Cyt19 protein CNNM2 10q24.32 cyclin M2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3950 - 700 - 2002 12167624
    13 - 3977 - 709 - 2002 12167624
    13 - 3947 - 699 - 2002 12167624
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines leukemia
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long serine-rich stretch interspersed with acidic residues (repeated 10 lines)
  • a LISH motif
  • N- and C-terminal domains bound respectively to alpha-satellite arrays and rDNA clusters of acrocentric chromosomes for nucleolar formation
  • a central acidic-and-basic repeated domain, possessing a weak self-self interacting ability, indispensable to build up a nucleolar round-shaped structure
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Mopp140
    intraspecies homolog to TCOF1
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • pre-rRNA processing factors such as DKC1, NOLC1 and fibrillarin (FBL) associate with r-chromatin during interphase but were released from r-chromatin in mitosis
  • dispersed between and around the chromosomes in prophase, from prometaphase to telophase, it was also detected in numerous cytoplasmic nucleolus-derived fociand during telophase, it reappeared in the reforming nucleoli of daughter nuclei (
  • basic FUNCTION
  • maintenance of nucleolar integrity (fundamental structure of the fibrillar center and dense fibrillar component)
  • mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene
  • scaffold protein, involved in the nucleolar assembly, fusion, and maintenance
  • could be a component implicated in the early steps of pre-rRNA processing
  • plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, genomic integrity
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase 1
  • both NOLC1 and TP53 work together synergistically to activate the MDM2 promoter in nasopharyngeal carcinoma (NPC) cells
  • transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs)
  • highly phosphorylated protein inhibitor of casein kinase 2 (CSNK2A1, CSNK2B1)
  • CSNK2A1 activity is inhibited by NOLC1 and reactivated by GPRIN2 by competitive binding at the substrate recognition site of CSNK2A1
  • rRNA gene chromatin (r-chromatin) association of NOLC1, DKC1, and FBL was dependent on the transcription factor upstream binding factor (UBF)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS