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FLASH GENE
Symbol NOL8 contributors: mct/npt - updated : 02-09-2008
HGNC name nucleolar protein 8
HGNC id 23387
Location 9q22.32      Physical location : 95.059.640 - 95.087.876
Synonym name
  • chromosome 9 open reading frame 34
  • nucleolar protein Nop132
  • Synonym symbol(s) NOP132, C9orf34, FLJ20736, bA62C3.3, bA62C3.4, DKFZp686P12242
    DNA
    TYPE functioning gene
    STRUCTURE 28.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located colocalized with RRAGA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4336 - 1167 - Sekiguchi (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousspinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an RNA recognition motif (RRM) at the N-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may be a global transcriptional regulator
  • may be involved in brain development and facial morphogenesis
  • functions in the recruitment of pre-rRNA processing proteins, including DDX47, to the region where rRNA is transcribed within the nucleolus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • associated with the GTP form of RRAGA
  • associated with RRAGC, RRAGD
  • interacting with NIP7
  • associated mainly with proteins involved in ribosome biogenesis and RNA metabolism, including the DEAD-box RNA helicase protein, DDX47
  • cell & other
    REGULATION
    Other probably regulated by RRAGA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in diffuse-type gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS