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FLASH GENE
Symbol NOG contributors: mct/npt - updated : 30-01-2014
HGNC name noggin
HGNC id 7866
Corresponding disease
BDB2 brachydactyly, type B2
SABT stapes ankylosis with broad thumb and toes
SYM1 symphalangism, proximal
SYNS1 deafness-symphalangism syndrome
Location 17q22      Physical location : 54.671.059 - 54.672.951
Synonym name
  • noggin, mouse, homolog of
  • neural inducing gene
  • synostoses (multiple) syndrome 1
  • symphalangism 1 (proximal)
  • Synonym symbol(s) SYM1, SYNS1
    DNA
    TYPE functioning gene
    STRUCTURE 1.89 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure intronless
    MAPPING cloned Y linked N status provisional
    Physical map
    TOM1L1 22q13 target of myb1-like 1 (chicken) COX11 17q21.31-q23 COX11 homolog, cytochrome c oxidase assembly protein (yeast) STXBP4 17q22 syntaxin binding protein 4 HLF 17q22 hepatic leukemia factor MMD 17q monocyte to macrophage differentiation-associated LOC390804 17 similar to Glycyl-tRNA synthetase (Glycine--tRNA ligase) (GlyRS) LOC342599 17q23.1 similar to PEPD protein FLJ10970 17q23.1 hypothetical protein FLJ10970 PCTP 17q21-q22 phosphatidylcholine transfer protein FLJ38335 17q23.1-q23.2 hypothetical protein FLJ38335 LOC342600 17q23.2 similar to hypothetical protein 4932411E22 NOG 17q22 noggin DGKE 17q22 diacylglycerol kinase, epsilon 64kDa ZNF147 17q22 zinc finger protein 147 (estrogen-responsive finger protein) COIL 17q22-q23 coilin RISC 17q23.2 coilin LOC376412 17q23.2 ring finger protein 126 pseudogene AKAP1 17q21-q23 a kinase (PRKA) anchor protein 1 MSI2 17q23.1 musashi homolog 2 (Drosophila) FLJ11710 17q23.2 hypothetical protein FLJ11710 MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1892 25 232 - 2009 19700758
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum  
     brainforebraincerebral cortex  
    Reproductivefemale systemuterus   
     female systemplacenta   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    Nervoustufted cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text developing bone, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus LOC363665
    homolog to murine Nog
    Homologene
    FAMILY
  • noggin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • Spemann organizer binding and inactivating BMP4 and other TGFB family members
  • involved in the joint formation and in skeletogenesis
  • playing a role in creating morphogenetic gradients
  • required for induction of the hair follicles growth phase in postnatal skin (through the modulation of BMP4)
  • soluble BMP antagonists, regulating the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition
  • bone morphogenetic protein antagonist promoting skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways (Sharov 2009)
  • may contribute to the myelofibrotic process characterized by bone marrow stromal reaction including collagen fibrosis, osteosclerosis, and angiogenesis (Andrieux 2007)
  • NOG and GREM1 cooperate potentialy to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction
  • glycosylated-secreted protein known so far for its inhibitory effects on bone morphogenetic protein (BMP) signaling by sequestering the BMP ligand
  • novel role for noggin as an inducer of adipogenesis
  • regulates both osteoblast and adipocyte differentiation of mesenchymal stemcell (MSC) and, hence, is a master regulator of MSC plasticity
  • BMP inhibitor, providing metastatic breast cancer cells with the ability to colonize the bone
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , nervous system
    text embryogenesis, morphogenesis and neurogenesis, bone development and maintenance, dorsal ventral polarity
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • homodimer disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP4 (inactivation of BMP4)
  • TGFB family of signaling proteins
  • harmonious interactions between NOGGIN and BMP4 in periodontal ligament-forming cells, which show higher cell proliferation than neighboring cells, might be important for proper periodontium development (Kim 2007)
  • apoptotic effect of BMP2 is dependent on cell maturation state, inducing apoptosis in committed osteoblasts through SMAD and TAB/TAK1 signaling, and is regulated by NOG
  • BMP4 antagonist NOG attenuates valve interstitial cells (VICs) activation and biomineralization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SYM1 , SYNS1 , SABT , BDB2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BMP6, NOG and SOST could be used in combination as a prognostic indicator in cancer progression
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential of noggin as a therapeutic target to control obesity
    ANIMAL & CELL MODELS
  • noggin knockout mice
  • required for mouse forebrain development
  • Obese mice with elevated noggin have reduced bone mineral density