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FLASH GENE
Symbol NOD1 contributors: mct - updated : 04-10-2014
HGNC name nucleotide-binding oligomerization domain containing 1
HGNC id 16390
Location 7p14.3      Physical location : 30.464.143 - 30.518.393
Synonym name
  • caspase recruitment domain family, member 4
  • NLR family, CARD domain containing 1
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
  • Synonym symbol(s) EVI145, CLAN, CARD4, CLR7.1, NLRC1
    DNA
    TYPE functioning gene
    STRUCTURE 54.25 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4506 - 953 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly Mus musculus
    Digestiveintestine    
     liver   highly Mus musculus
    Reproductivefemale systemovary   
    Respiratorylung   highly
    Urinarykidneytubule    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines cancer cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta early embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal CARD (caspase recruitment) domain including a P loop (Walker A) and a Mg2+ binding site
  • a central nucleotide binding domain
  • a NAD and NACHT domain
  • ten tandem leucine-rich repeats at the C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans Card4
    Homologene
    FAMILY
  • APAF protein family
  • CARD family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • activator of caspase 9 to induce apoptosis
  • playing a role in colonic epithelial defences against intracellular organisms
  • playing a role in host responses to invasive bacteria and controlling tumor formation
  • NOD1 and NOD2 play an important role in the pathogenesis of acute ischemic injury of the kidney, although possibly through different mechanisms
  • role in the development of site-specific vascular inflammation, especially coronary arteritis
  • might function as an alternative costimulatory receptor in CD8 T cells
  • its activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis
  • is a component of innate immunity involved in insulin resistance
  • NOD1 and NOD2 are intracellular pattern recognition receptors that activate inflammation and autophagy
  • intracellular pathogen recognition receptor that contributes to anti-bacterial innate immune responses, adaptive immunity and tissue homeostasis
  • is involved in alveolar macrophages and monocyte-derived macrophages innate responses, which include proinflammatory cytokines and autophagy, with potential implications in the killing of Mycobacterium tuberculosis (Mtb)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text may be a component of host innate immunity
    PATHWAY
    metabolism
    signaling signal transduction
    a component SSH1 is a specific and essential component of the NOD1 pathway
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating CASP9, other caspases
  • RIPK2 determines its stability and consequently NOD1- and NOD2-mediated immune responses
  • role for XIAP in regulating innate immune responses by interacting with NOD1 and NOD2 through interaction with RIPK2
  • NLRP10 interacts with NOD1, a NLR that is pivotally involved in sensing of invasive microbes, and both proteins are recruited to the bacterial entry point at the plasma membrane
  • NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells
  • NOD1 CARD binds ubiquitin (Ub), in addition to directly binding its downstream targets receptor-interacting protein kinase 2 (RIPK2) and autophagy-related protein 16-1 (ATG16L1)
  • PSMA7 is a negative regulator of the NOD1, and may promote tumor growth by its inhibitory role on NOD1
  • RNF34 is a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1, and suggest a novel regulatory mechanism of NOD1
  • cell & other NFKB via RIPK2
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in estrogen-dependent tumor growth
    Susceptibility
  • to asthma
  • to early onset inflammatory bowel disease(IBD)
  • Variant & Polymorphism SNP , other
  • SNP increasing the risk of asthma and elevated IgE
  • polymorphism associated with early onset inflammatory bowel disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS