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Symbol NOC3L contributors: mct/npt - updated : 25-06-2008
HGNC name nucleolar complex associated 3 homolog (S. cerevisiae)
HGNC id 24034
Location 10q23.33      Physical location : 96.092.988 - 96.122.683
Synonym name
  • factor for adipocyte differentiation 24
  • chromosome 10 open reading frame 117
  • nucleolar complex-associated protein 3-like protein
  • Synonym symbol(s) AD24, C10orf117, FAD24, FLJ12820
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3475 92.5 800 - Nousiainen (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic leucine zipper motif
  • a NOC domain
  • HOMOLOGY
    interspecies ortholog to yeast Noc3p
    Homologene
    FAMILY
  • CBF/MAK21 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • may function as one of the components for transcription and/or pre-mRNA splicing and positively regulates adipocyte differentiation
  • promotes adipogenesis by controlling DNA replication early on during a stage referred to as mitotic clonal expansion
  • plays positive roles in the proliferation of pre-confluent cells as well as adipogenesis
  • playing a rolein the repression of NFKB1 activity and HRAS-mediated transformation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibits HRAS-induced transformation by negatively regulating NFKB1 activity
  • interacting with MYST2 (an interacting partner of NOC3L, also inhibiting transformation by HRAS)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS