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FLASH GENE
Symbol NNMT contributors: mct/npt - updated : 26-02-2009
HGNC name nicotinamide N-methyltransferase
HGNC id 7861
Location 11q23.1      Physical location : 114.166.534 - 114.183.238
EC.number 2.1.1.1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 16.70 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IL18 11q22.2-q22.3 interleukin 18 (interferon-gamma-inducing factor) TEX12 11q22 testis expressed sequence 12 BCDO2 11q22.3-q23.1 beta-carotene dioxygenase 2 MRPS36P4 11q23.2 mitochondrial ribosomal protein S36 pseudogene PTS 11q22.3-q23.3 6-pyruvoyltetrahydropterin synthase PLET1 11q23.2 placenta expressed transcript 1 LOC387809 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein LOC387810 11 LOC387810 NCAM1 11q23.1 neural cell adhesion molecule 1 TTC12 11q23.2 tetratricopeptide repeat domain 12 ANKK1 11q23.2 ankyrin repeat and kinase domain containing 1 DRD2 11q23.1 dopamine receptor D2 TMPRSS5 11q23 transmembrane protease, serine 5 (spinesin) ZW10 11q22-q23.3 ZW10 homolog, centromere/kinetochore protein (Drosophila) LOC255244 11q23.3 similar to Claudin-22 LOC390251 11 hypothetical gene supported by AK093353 LOC143920 11q23.3 similar to activating transcription factor 4; cAMP response element-binding protein 2 USP28 11q23 ubiquitin specific protease 28 HTR3B 11q23.1-q23.2 5-hydroxytryptamine (serotonin) receptor 3B HTR3A 11q23.1-q23.2 5-hydroxytryptamine (serotonin) receptor 3A ZNF145 11q23.1 zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia) NNMT 11q23.1 nicotinamide N-methyltransferase FLJ20010 11q14.2-q14.3 hypothetical protein FLJ20010 RBM7 11q23.1-q23.2 RNA binding motif protein 7 DKFZP566E144 11q23.1-q23.2 small fragment nuclease MGC34290 11q23.3 hypothetical protein MGC34290 C11orf33 11q23.3 chromosome 11 open reading frame 33 LOC390252 11 similar to putative protein family member (XC187) LOC390253 11 similar to putative protein family member (XC187) FLJ25224 11q23.3 hypothetical protein FLJ25224 IGSF4 11q23.2 immunoglobulin superfamily, member 4 LOC387811 11 similar to hypothetical protein FLJ25224
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1579 29.44 264 - Aksoy (1995)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivefemale systemuteruscervix  
 female systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • NNMT/PNMT/TEMT family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the N-methylation of nicotinamide and other pyridines to form pyridinium ions (activity important for biotransformation of many drugs and xenobiotic compounds)
  • having a necessary role for cancer cell migration (Wu 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STAT3-regulated gene(its expression is enhanced with the activation of STAT3 in colon cancer tissues (Tomida 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancer
    Susceptibility
  • to modification of plasma homocysteine levels
  • to venous thrombosis, myocardial infarction, stroke, congestive heart failure
  • abdominal aortic aneurysm
  • to abdominal aortic aneurysm (Giusti 2008)
  • to osteoporotic fractures
  • to Alzheimer disease
  • Variant & Polymorphism
    Candidate gene potential candidate for a tumor marker of various kinds of cancers (Tomida 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS