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FLASH GENE
Symbol NMU contributors: KTN/npt - updated : 02-04-2008
HGNC name neuromedin U
HGNC id 7859
Location 4q12      Physical location : 56.461.404 - 56.502.465
Synonym name neuromedin-U-25
DNA
TYPE functioning gene
STRUCTURE 41.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D4S1619 - NMU - D5S1592 - D4S398 - D4S1541 - D4S409 - D4S392 - cen
Authors Gene Map (98)
Physical map
PDGFRA 4q11-q12 platelet-derived growth factor receptor, alpha polypeptide LOC254938 4q12 hypothetical LOC254938 KIT 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654 GLDCP 4q12 glycine dehydrogenase (decarboxylase) pseudogene HOP 4q11-q12 homeodomain-only protein LOC391655 4 similar to 60S ribosomal protein L17 (L23) LOC285453 4q12 similar to APACD protein SPINK2 4q12 serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor) REST 4q12 RE1-silencing transcription factor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 817 - 174 - Wu (2007)
  • a 34 aa signal peptide of 3.6 kda
  • a 33 aa mature peptide of 3.9 kda
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     pharynx   moderately
     stomach   moderately
    Nervousbraindiencephalonhypothalamus  
    Reproductivefemale systemovary  highly
     female systemuteruscervix moderately
    Respiratoryrespiratory tractlarynx  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connective   highly
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four potential proteolytic processing sites generating putative associated peptides
  • conjugated Other
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to dog NMU (82.4 pc)
    homolog to chimpanzee NMU (99.4 pc)
    homolog to rattus Nmu (72.1 pc)
    homolog to murine Nmu (74.4 pc)
    homolog to chicken NMU (63 pc)
    Homologene
    FAMILY
  • NmU family
  • CATEGORY regulatory , secretory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • central control of feeding and potent uterine contractile effets, involved in feeding behavior as a catabolic signaling molecule
  • stimulating contractions of the ileum and urinary bladder
  • plays a role in feeding behavior and catabolic functions via CRH (corticotrophin-releasing hormone)
  • acting in the central nervous system, rather than directly on bone cells, to regulate bone remodeling
  • acting as a neuropeptide
  • involved in the regulation of smooth muscle contraction
  • involved in energy regulation
  • implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion , reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/hearing
  • neuropeptide signaling pathway
  • a component
  • amidation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NMU/NMU1R axis constitutes a growth-promoting autocrine loop in myeloid leukemia cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    deficiency results in an isolated increase in bone formation leading to high bone mass
    Susceptibility associated with overweight and obesity
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for the treatment of lung cancers
    ANIMAL & CELL MODELS