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FLASH GENE
Symbol NMRAL1 contributors: mct - updated : 14-03-2015
HGNC name NmrA-like family domain containing 1
HGNC id 24987
Location 16p13.3      Physical location : 4.511.695 - 4.524.896
Synonym name short chain dehydrogenase/reductase family 48A, member 1
Synonym symbol(s) HSCARG, SDR48A1
DNA
TYPE functioning gene
STRUCTURE 13.21 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1401 - 299 - 2009 19254724
- - 1271 - 299 - 2009 19254724
- - 1284 - 299 - 2009 19254724
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text
  • could shuttle between the nucleus and cytoplasm by sensing the change in cellular redox states
  • basic FUNCTION
  • negatively regulates NF-kappaB activation
  • nuclear factor-kappaB (NFKB) inhibitor that plays important roles in cell growth
  • nucleocytoplasmic translocation of NMRAL1 plays an important role in fine-tuning NFKB signaling
  • is a novel regulator in regulation of the activity of NADPH oxidase and ROS homeostasis
  • is a new negative regulatory protein for H2A ubiquitination
  • participates in innate immunity
  • is a negative regulator that enables balanced antiviral innate immunity
  • suppresses TNF-stimulated NFKB signaling under physiological conditions
  • NMRAL1 and USP7 function in concert in inhibiting polyubiquination of IKBKG, thus inhibiting NFKB activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with COMMD1, an inhibitor of NF-kappaB, and negatively regulate COMMD1 by accelerating its ubiquitination and proteasome-dependent degradation
  • suppresses TNF- and IL1-induced NF-kappaB activation in a dose-dependent manner
  • interacts and colocalizes with IKBKB, and inhibits the phosphorylation of IKBKB
  • regulates NCF1 through inhibition of NFKB activity
  • interacts with polycomb repressive complex 1 (PRC1) and deubiquitinase USP7 and inhibits PRC1 ubiquitination in a USP7-dependent manner
  • interacted with TRAF3 and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3
  • interacts with IKBKG and suppresses polyubiquitination of IKBKG by interacting with the deubiquitinase USP7
  • cell & other
    REGULATION
    Other NADPH functions as an allosteric regulator of the structure and function of NMRAL1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS