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FLASH GENE

Symbol

NMI

contributors: mct - updated : 21-10-2016

HGNC name	N-myc (and STAT) interactor
HGNC id	7854

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q23.3      Physical location : 152.126.981 - 152.146.430
Synonym name	N-myc interactor

DNA

TYPE	functioning gene
STRUCTURE	19.45 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004688 8 - 1501 NP_004679 35 307 - 2009 19358268

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	cancer cell lines, myeloid leukemia, highly
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	at low levels in all tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal region homolog to a coiled-coil heptad repeat in C elegans protein CEF59
	NID repeats, a region essential for the cytoplamic localization and homo- and heterodimerization of NMI
	a C terminal homolog to an interferon induced leucine zipper protein, lacking a transactivation domain

HOMOLOGY

intraspecies

homolog to IFI35

Homologene

FAMILY

NMI family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies
text	translocated with IFI35 in nuclear speckles

basic FUNCTION	increasing STA mediated transcription in response to IL2 and IFNG by enhancing the association of CBP/P300 coactivator proteins with IL2 and IFNG
	transcription cofactor that augments IFN-gamma induced transcription activity
	is an ERN1-interacting/modulator protein in human pancreatic beta cells
	NMI induction is a novel negative feedback mechanism that decreases ERN1-dependent activation of JNK and apoptosis in cytokine-exposed beta cells
	has a role as a positive regulator of HSP105 beta-mediated HSPA4 gene expression along the STAT3 signaling pathway

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

novel NMI-mediated, transcription-independent CDKN2A induction pathway in response to cellular stresses

a component

component of a complex with IF135, BATF

INTERACTION

DNA

RNA

small molecule

protein	binding to c-myc and n-myc, Max transcription factors carrying leucine zipper or helix-loop-helix or HLH-leucine zypper motifs
	IFI35 and its homologue NMI are two novel PLEKHO1 interacting partners
	is a novel binding partner for KAT5, that interacts with the NID repeats of NMI, a region essential for the cytoplamic localization and homo- and heterodimerization of NMI
	is a novel CDKN2A-interacting protein, and a MYC-interacting protein
	is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7
	NMI is an Hsp105 beta-binding protein
	DRAM1 is regulated by NMI
	TRIM21 is an interacting partner of IFI35 and NMI, and TRIM21 appears to be a critical regulator of the functions of the NMI-IFI35 complex
	IRF1 is involved in the IFN-inducible expression of NMI

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   promotes epithelial-mesenchymal-transition and results in enhanced invasive ability of breast cancer cells tumoral     --over   inhibits the Wnt/beta-catenin signaling via up-regulation of DKK1 and retards tumor growth

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

increased expression of Nmi was detected in islets from nonobese diabetic mice with insulitis