basic FUNCTION
| catalyzes non-substrate specific conversions of nucleoside diphosphate to nucleoside triphosphate |
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may have a role in spindle assembly and cytokinesis (Hutchins 2010) |
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importance of NME6 and NME7 in embryonic stem cells (ESCs) renewal |
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NME7 promotes gamma-tubulin ring complex (gammaTuRC) -dependent nucleation of microtubules, but kinase-deficient NME7 does so only poorly |
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NME7 likely functions in the gammaTuRC in a kinase-dependent manner to facilitate microtubule nucleation |
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laterality patterning role for NME7 |
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NME1, NME5, NME7, and NME8 also exhibit a 3'-5' exonuclease activity, suggesting roles in DNA proofreading and repair |
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role of the centrosomally located NME7 gene in ciliogenesis and control of ciliary transport |
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implication of NME7 in the pathogenesis of glucose intolerance and adiposity |