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FLASH GENE
Symbol NME7 contributors: mct - updated : 27-12-2023
HGNC name non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
HGNC id 20461
Location 1q24.2      Physical location : 169.101.770 - 169.337.186
Synonym name
  • nucleoside diphosphate kinase 7
  • NDP kinase 7
  • cilia and flagella associated protein 67
  • Synonym symbol(s) NM23-H7, FLJ37194, NDK7
    EC.number 2.7.4.6
    DNA
    TYPE functioning gene
    STRUCTURE 235.42 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1472 42 376 - 2000 11768308
  • isoform a
  • 12 - 1615 - 340 - 2000 11768308
  • isoform b
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  lowly
     liver   lowly
    Lymphoid/Immunespleen   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
     male systemtestis  highly
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one DM10 domain
  • two putative kinase domains, A and B, with autophosphorylating activity
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nme7 (88.3pc)
    homolog to rattus Nme7 (87.2pc)
    Homologene
    FAMILY
  • nucleoside diphosphate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • in association with the gammaTuRC, NME7 localizes to centrosomes throughout the cell cycle and to mitotic spindles during mitosis
  • basic FUNCTION
  • catalyzes non-substrate specific conversions of nucleoside diphosphate to nucleoside triphosphate
  • may have a role in spindle assembly and cytokinesis (Hutchins 2010)
  • importance of NME6 and NME7 in embryonic stem cells (ESCs) renewal
  • NME7 promotes gamma-tubulin ring complex (gammaTuRC) -dependent nucleation of microtubules, but kinase-deficient NME7 does so only poorly
  • NME7 likely functions in the gammaTuRC in a kinase-dependent manner to facilitate microtubule nucleation
  • laterality patterning role for NME7
  • NME1, NME5, NME7, and NME8 also exhibit a 3'-5' exonuclease activity, suggesting roles in DNA proofreading and repair
  • role of the centrosomally located NME7 gene in ciliogenesis and control of ciliary transport
  • implication of NME7 in the pathogenesis of glucose intolerance and adiposity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • ATP binding
  • cofactor Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    hmozygous NME7 mutation is associated with Situs Inversus Totalis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knock-out of the rat Nme7 gene resulted in a range of conditions consistent with the presentation of primary ciliary dyskinesia