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FLASH GENE
Symbol NME5 contributors: mct - updated : 21-08-2012
HGNC name non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
HGNC id 7853
Location 5q31.2      Physical location : 137.450.861 - 137.475.132
Synonym name
  • NDP kinase homolog 5
  • IPIA-beta
  • radial spoke 23 homolog
  • testis-specific nm23 homolog
  • Synonym symbol(s) NM23-H5, NM23H5, RSPH23
    EC.number 2.7.4.6
    DNA
    TYPE functioning gene
    STRUCTURE 24.27 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • two functional GC-boxes (-300 bp and -323 bp) were identified within the promoter region
  • overexpression of SP1 activated NME5 promoter activity in pancreatic cancer cells
  • MAPPING cloned Y linked   status provisional
    Map cen - D5S500 - EGR1 - NME5 - CTNNA1 - FGF1 - D5S2119 - D5S402 - D5S436 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1243 - 212 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Reproductivefemale systemovary   
     female systemuterus   
     male systemtestis  highly Homo sapiens
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage specifically, in testis germinal cells, germ cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain and a C terminal extension
  • HOMOLOGY
    interspecies homolog to murine Nm23-M5
    Homologene
    FAMILY
  • nm23 nucleoside diphosphate kinase gene family
  • NDPK-like molecules gene family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the phosphorylation of nucleoside diphosphates and putatively in spermatogenesis
  • may have specific functions in the phosphotransfer network involved in spermiogenesis and flagellar movement
  • its expression plays a critical role in spermiogenesis by increasing the cellular levels of GPX5 to eliminate reactive oxygen species
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in urothelial carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS