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FLASH GENE
Symbol NME3 contributors: - updated : 21-08-2007
HGNC name non-metastatic cells 3, protein expressed in
HGNC id 7851
Location 16q13      Physical location : 1.820.321 - 1.821.710
Synonym name nucleoside diphosphate kinase 3
Synonym symbol(s) DR-NM23, KIAA0516
EC.number 2.7.4.6
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor
text structure
  • no TATA box, two binding sites for AP-2
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage preferentially, at early stage of myeloid differentiation, hematopoietic cells
    cell lines cell tumor lines (carcinoma of breast colon)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    intraspecies homolog to homolog to nucleoside diphosphate kinase 3
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibiting granulocyte differentiation and inducing apoptosis
  • involved in the phosphorylation of nucleoside diphosphates
  • playing a role in normal hematopoiesis
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myelogenous leukemia (differentiation arrest and blastic transformation)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS