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FLASH GENE

Symbol

NME3

contributors: - updated : 21-08-2007

HGNC name	non-metastatic cells 3, protein expressed in
HGNC id	7851

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q13      Physical location : 1.820.321 - 1.821.710
Synonym name	nucleoside diphosphate kinase 3
Synonym symbol(s)	DR-NM23, KIAA0516
EC.number	2.7.4.6

DNA

TYPE	functioning gene
STRUCTURE	1.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	Binding site   transcription factor
text structure	no TATA box, two binding sites for AP-2

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine pancreas       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage	preferentially, at early stage of myeloid differentiation, hematopoietic cells
cell lines	cell tumor lines (carcinoma of breast colon)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative leucine-zipper domain
	a Kpn (Drosophila Killer of prune) loop
	a RGD domain
	a C terminal extension preceded by the YEEEEP motifs

HOMOLOGY

intraspecies

homolog to homolog to nucleoside diphosphate kinase 3

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	inhibiting granulocyte differentiation and inducing apoptosis
	involved in the phosphorylation of nucleoside diphosphates
	playing a role in normal hematopoiesis

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

nucleotide

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chronic myelogenous leukemia (differentiation arrest and blastic transformation)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS