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FLASH GENE
Symbol NME3 contributors: mct - updated : 27-12-2023
HGNC name non-metastatic cells 3, protein expressed in
HGNC id 7851
Location 16p13.3      Physical location : 1.820.321 - 1.821.710
Synonym name nucleoside diphosphate kinase 3
Synonym symbol(s) DR-NM23, KIAA0516, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2
EC.number 2.7.4.6
DNA
TYPE functioning gene
STRUCTURE 1.22 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor
text structure
  • no TATA box, two binding sites for AP-2
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 848 - 169 - 2020 32708927
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage preferentially, at early stage of myeloid differentiation, hematopoietic cells
    cell lines cell tumor lines (carcinoma of breast colon)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    interspecies homolog to Dynamo1
    intraspecies homolog to homolog to nucleoside diphosphate kinase 3
    Homologene
    FAMILY nucleoside diphosphate kinase (NDPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • endogenous NME3 localizes to the basal body and that it associates also with centrosomal proteins, such as NEK6, which regulates cell cycle arrest after DNA damage
  • basic FUNCTION
  • inhibiting granulocyte differentiation and inducing apoptosis
  • involved in the phosphorylation of nucleoside diphosphates
  • playing a role in normal hematopoiesis
  • NME1 and, more recently, NME3, have been implicated in repair of both single- and double-stranded breaks in DNA
  • separate functions of NME3 in mitochondrial fusion and NDP kinase cooperate in metabolic adaptation for cell survival in response to glucose starvation
  • contribution of NME3 to redox-regulated genome stability lies in its function in mitochondrial fusion
  • NME3 plays likely an important role in peroxisome division in a manner dependent on its NDP kinase activity
  • NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NME3 as one specific NDP kinase that interacts directly with Tip60, a histone acetyltransferase, to form a complex with RNR (ribonucleotide reductase)
  • NME3 binds to several NPHPs, including NEK8, CEP164, and ankyrin repeat and sterile &
  • 945; motif domain-containing 6 (ANKS6)
  • NME3, is required for PLD6-induced mitochondrial tethering or clustering
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myelogenous leukemia (differentiation arrest and blastic transformation)
    constitutional germinal mutation      
    may aggravate the ciliopathy phenotypes observed in humans
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS