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FLASH GENE
Symbol NMBR contributors: mct/npt - updated : 13-06-2008
HGNC name neuromedin B receptor
HGNC id 7843
Location 6q23      Physical location : 142.396.745 - 142.409.936
Synonym name
  • bombesin-like peptide receptor
  • neuromedin-B-preferring bombesin receptor
    • Synonym symbol(s) NMB-R
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1354 43.4 390 - Matusiak (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • neuromedin B are mitogens in both normal and malignant epithelial cells lining the colon
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS