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FLASH GENE
Symbol NLRP14 contributors: mct - updated : 08-01-2007
HGNC name NLR family, pyrin domain containing 14
HGNC id 22939
Location 11p15.4      Physical location : 7.041.699 - 7.092.757
Synonym name
  • NACHT, leucine rich repeat and PYD containing 14
  • nucleotide-binding oligomerization domain protein 5
  • caterpiller ((CARD, Transcription Enhancer, R (purine)-binding, Pyrin, Lots of Leucine Repeats)11.2
  • Synonym symbol(s) NOD5, CLR11.2, GC-LRR, NALP14, PAN8
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of PYPAF genes
    STRUCTURE 32.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  predominantly
    Respiratoryrespiratory tracttrachea   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one DAPIN domain,
  • one NACHT domain
  • eleven leucine-rich repeats (LRRs)
  • HOMOLOGY
    Homologene
    FAMILY NOD (nucleotide-binding oligomerization domain) proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be part of inflammasomes complexes
  • may activates proinflammatory caspases 1 and 5
  • function as cytosolic sensors for the induction of apoptosis, as well as for innate recognition of microorganisms and regulation of inflammatory responses
  • has a function in spermatogenesis and mutations in this gene might cause spermatogenic failure
  • implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cells response to microbial infection (Tschopp 2003)
  • play important roles in both mammalian innate immune system and reproductive system (Tian 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS