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FLASH GENE
Symbol NLRP11 contributors: mct - updated : 10-01-2007
HGNC name NLR family, pyrin domain containing 11
HGNC id 22945
Location 19q13.43      Physical location : 56.296.769 - 56.348.128
Synonym name
  • PYRIN-containing APAF1-like protein 6
  • NACHT, leucine rich repeat and PYD containing 11
  • PAAD- and NACHT-containing protein 10
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11
  • caterpiller ((CARD, Transcription Enhancer, R (purine)-binding, Pyrin, Lots of Leucine Repeats)19.6
  • Synonym symbol(s) PYPAF6, NOD17, CLR19.6, FLJ26273, NALP11, PAN10, PYPAF7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of PYPAF genes
    STRUCTURE 46.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Lymphoid/Immunetonsils    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines lymphoma, primary B cells from tonsils
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal PYN (Pyrin-PAAD-Dapin) domain, necessary and sufficient for suppression of NFKB1 activation
  • a nucleotide binding site (NBS-NATCH subfamily), involved in interaction with CARD8
  • 9 leucine rich repeats
  • HOMOLOGY
    Homologene
    FAMILY nucleotide binding site (NB)/LRR family, caterpiller family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in inflammation
  • may be implicated in apoptosis
  • may be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases
  • implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cells response to microbial infection (Tschopp 2003)
  • play important roles in both mammalian innate immune system and reproductive system (Tian 2009)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein recruited by PYCARD to distinct cytoplasmic loci and inducing NF-kappa B activation
    cell & other
    REGULATION
    induced by interferons and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS