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FLASH GENE
Symbol NLRC3 contributors: mct - updated : 08-04-2013
HGNC name NLR family, CARD domain containing 3
HGNC id 29889
Location 16p13.3      Physical location : 3.589.037 - 3.627.392
Genatlas name NOD3 protein
Synonym name
  • CARD15-like
  • caterpiller 16.2, CARD, transcription enhancer , R(purine)-binding, pyrin, lots of leucine repeats 16.2
  • NOD-like receptor C3
  • Synonym symbol(s) CLR16.2, FLJ00348, NOD3
    DNA
    TYPE functioning gene
    STRUCTURE 38.36 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 6401 - 1065 - 2005 15870018
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbrain    
    Reproductivefemale systemuterus   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal effector-binding domain
  • a nucleotide-binding oligomerization domain
  • a C-terminal leucine-rich sensor domain
  • HOMOLOGY
    Homologene
    FAMILY NOD (nucleotide-binding oligomerization domain) proteins family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulating T cell function
  • function as cytosolic sensors for the induction of apoptosis, as well as for innate recognition of microorganisms and regulation of inflammatory responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibited TLR-dependent activation of the transcription factor NFKB1 by interacting with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NFKB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS