Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NLK contributors: mct/npt - updated : 02-01-2014
HGNC name nemo-like kinase
HGNC id 29858
Location 17q11.2      Physical location : 26.369.687 - 26.523.402
Synonym name protein LAK1
Synonym symbol(s) DKFZp761G1211, FLJ21033, LAK1
EC.number 2.7.11.24
DNA
TYPE functioning gene
STRUCTURE 153.72 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KSR 17q11.1 kinase suppressor of ras LGALS9 17q11.1 lectin, galactoside-binding, soluble, 9 (galectin 9) LOC390780 17 similar to ubiquitin specific protease 6; tre-2 oncogene; hyperpolymorphic gene 1 LOC390781 17 similar to galectin-9 NOS2A 17q11.2 nitric oxide synthase 2A (inducible, hepatocytes) LOC390782 17 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) NLK 17q11.2 nemo-like kinase PYY2 17q11.1-q11.2 peptide YY, 2 (seminalplasmin) PPY2 17q11.1-q11.2 pancreatic polypeptide 2 LOC339274 17q11.2 similar to Hypothetical protein KIAA0563 FLJ40504 17q11.2 hypothetical protein FLJ40504 MAC30 17q11.2 hypothetical protein FLJ40504 LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3555 - 527 - 2002 12039044
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Urinarykidney    
Visualeyeretina  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 289 AA kinase domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
  • CATEGORY regulatory , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a novel role in the regulatory of SMAD4 through phosphorylation
  • suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex
  • suppresses Notch signalling by interfering with formation of the Notch active transcriptional complexconserved serine/threonine kinase that suppresses beta-catenin/T-cell factor (TCF) complex transcriptional activity through phosphorylation of TCF
  • its expression is altered during prostate cancer progression and is involved in regulation of AR signaling in these cells
  • induces apoptosis in glioma cells via activation of caspases
  • potentially serves as a conserved molecular link between core planar cell polarity factors and E-cadherin-CTNNB complexes, promoting cell motility
  • potential clock kinase
  • suppressor of tumor necrosis factor (TNF)-induced NFKB1 signaling by inhibiting the phosphorylation of IKBKB
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • transforming growth factor-beta-activated kinase (MAP3K7)-Nemo-like kinase (NLK) pathway negatively regulates FOXO1
  • a component
  • homodimerization of NLK is required for its activation and nuclear localization (dimerization is an initial key event required for the functional activation of NLK)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds and phosphorylates FOXO1 at Pro-directed Ser/Thr residues in the transactivation domain
  • is a DAPK3 -binding partner and DAPK3 regulates NLK-mediated repression of canonical Wnt/beta-catenin signaling
  • functions as a pivotal negative regulator in TNF-induced activation of NFKB1 via disrupting the interaction of MAP3K7 with IKBKB
  • nuclear localization of NLK was mediated through direct interaction with HSPB1 which further protected cancer cells from apoptosis
  • cell & other
    REGULATION
    activated by Wnt1-induced MAP3K7 stimulation
    intermolecular autophosphorylation of NLK dimers at Thr-286
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with poor prognosis in glioma
    tumoral     --low  
    in prostate cancer metastases in comparison to normal prostate epithelium and primary cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    upregulating NLK expression could be developed for treatment of glioma
    ANIMAL & CELL MODELS