protein
| MDGA1, MDGA2 bind to NLGN2, a cell-adhesion molecule of inhibitory synapses, but do not bind detectably to NLGN1 or NLGN3, and inhibit the activity of NLGN2 in controlling the function of inhibitory synapses |
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in addition to its conventional role as a cell adhesion molecule to regulate GABAergic synaptogenesis, NLGN2 also regulates SLC12A5 to modulate GABA functional switch and even glutamatergic synapses |
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IGSF9B was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein MAGI2 |
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NLGN2 is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein GPHN in the post-synaptic density |
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PIN1-dependent signalling represents a mechanism to modulate GABAergic transmission by regulating NLGN2/GPHN interaction |
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GSK3B regulates the sorting of GPHN and NLGN2 complexes in a KIF5A-dependent manner |