Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NLGN2 contributors: mct/npt/pgu - updated : 09-11-2016
HGNC name neuroligin 2
HGNC id 14290
Location 17p13.1      Physical location : 7.311.501 - 7.323.179
Synonym name likely ortholog of rat neuroligin 2
Synonym symbol(s) KIAA1366, NLG2
DNA
TYPE functioning gene
STRUCTURE 11.68 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1 KCTD11 17p13.2 potassium channel tetramerisation domain containing 11 LOC339168 17p13.2 hypothetical protein LOC339168 TNK1 17p13.1 tyrosine kinase, non-receptor, 1 PLSCR3 17p13.2 phospholipid scramblase 3 MGC40107 17p13.2 hypothetical protein MGC40107 NLGN2 17p13 neuroligin 2 LOC374768 17p13.2 hypothetical protein LOC374768 LOC201243 17p13.2 hypothetical protein LOC201243 LOC388329 17 similar to ENSANGP00000015193 FLJ36878 17p13.2 hypothetical protein FLJ36878 LOC388330 17 LOC388330 FGF11 17p13.1 fibroblast growth factor 11 CHRNB1 17p13.1 cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) ZBTB4 17p13.2 zinc finger and BTB domain containing 4 POLR2A 17p13.1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4642 - 835 - 2000 10892652
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemovary   
 male systemtestis   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal hydrophobic sequence with the characteristics of a cleaved signal peptide
  • a large esterase homology domain
  • a highly conserved transmembrane region
  • a short cytoplasmic domain
  • HOMOLOGY
    intraspecies homolog to NLGN3 and NLGN4
    Homologene
    FAMILY
  • type-B carboxylesterase/lipase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating cell to cell interactions between neurons
  • triggering presynaptic development in contacting axon
  • having a role in nervous system development and maintenance
  • postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)
  • NLGN1 and NLGN2 are essential for excitatory and inhibitory synaptic functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text formation and remodeling of central nervous system synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MDGA1, MDGA2 bind to NLGN2, a cell-adhesion molecule of inhibitory synapses, but do not bind detectably to NLGN1 or NLGN3, and inhibit the activity of NLGN2 in controlling the function of inhibitory synapses
  • in addition to its conventional role as a cell adhesion molecule to regulate GABAergic synaptogenesis, NLGN2 also regulates SLC12A5 to modulate GABA functional switch and even glutamatergic synapses
  • NLGN2 is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein GPHN in the post-synaptic density
  • PIN1-dependent signalling represents a mechanism to modulate GABAergic transmission by regulating NLGN2/GPHN interaction
  • GSK3B regulates the sorting of GPHN and NLGN2 complexes in a KIF5A-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    NLGN2 R215H mutant is a loss-of-function mutant that is largely retained in the ER and is deficient in post-translational modification and surface expression, and associated to schizophrenia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS