basic FUNCTION
| putatively involved in islet development and/or regulation of insulin biosynthesis |
|
in the pancreas, required for the development of beta-cells and believed to function as a potent repressor of transcription upon binding to A/T-rich sequences within the promoter region of target genes |
|
bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events |
|
distinct requirements for NKX6-1 and NKX6-2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities |
|
both NKX6-1 and NKX6-2 possess alpha- and beta-cell-specifying activities |
|
is among the very rare factors capable of stimulating beta-cell replication with retention or enhancement of function |
|
novel regulator of HNF1alpha in pancreatic beta cells |
|
potential role for NKX6-1 in promoting PDX1 reprogrammed cells maturation along the beta-cell-like lineage |
|
is both necessary and sufficient to specify insulin-producing beta cells |
|
controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity |
|
NKX6-1-controlled gene regulatory network is essential for maintaining the functional and molecular traits of mature beta cells |