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FLASH GENE
Symbol NKX2-8 contributors: mct/npt - updated : 03-07-2009
HGNC name NK2 homeobox 8
HGNC id 16364
Location 14q13.3      Physical location : 37.049.216 - 37.051.786
Synonym name
  • NK-2 (Drosophila) homolog 8
  • NK2 transcription factor related, locus 8 (Drosophila)
  • homeobox protein NK-2 homolog H
  • Synonym symbol(s) NKX2H, Nkx2-9, NKX2G
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text head to head with PAX9
    STRUCTURE 2.57 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like LOC390468 14 similar to Plasmodium falciparum trophozoite antigen r45-like protein LOC390469 14 similar to interleukin enhancer binding factor 2 MBIP 14q13 similar to interleukin enhancer binding factor 2 LOC387985 14 hypothetical gene supported by AY102071 TITF1 14q13.1-q13.2 thyroid transcription factor 1 PHKBP2 14q13.2 phosphorylase kinase, beta pseudogene 2 NKX2-8 14q13.1-p13.2 NK2 transcription factor related, locus 8 (Drosophila) PAX9 14q12-q13.1 paired box gene 9 SLC25A21 14q11.2 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 MIPOL1 14q13.3 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 FOXA1 14q12-q13 forkhead box A1 TTC6 14q13.2 tetratricopeptide repeat domain 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1857 25.7 239 - Kajiyama (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one homeobox domain
  • HOMOLOGY
    intraspecies paralog to TITF1
    Homologene
    FAMILY
  • NK-2 homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • homeodomain transcription factor, having a role in progenitor cells in the large airways and leads to dysplasia (Tian 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding promoter-coupling element and regulating expression of alpha-fetoprrotein (AFP) gene
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    coactivation of NKX2-1 and NKX28 pathways in non-small-cell lung cancer resistant to standard cisplatin therapy and with poor prognosis (Hsu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS